INT153065

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 8.57
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 21 94.64 High High
Inflammation 73 92.08 High High
ischemia 15 90.16 High High
imagery 103 83.56 Quite High
Pain 2 65.64 Quite High
Inflammatory response 12 61.08 Quite High
Inflammatory stimuli 1 56.56 Quite High
Tetrahydrobiopterin 4 48.88 Quite Low
fibrosis 3 33.20 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 133 100.00 Very High Very High Very High
Targeted Disruption 53 99.46 Very High Very High Very High
Heterotopic Ossification 4 98.60 Very High Very High Very High
Infection 271 98.40 Very High Very High Very High
Cancer 85 98.28 Very High Very High Very High
Metaplasia 4 97.44 Very High Very High Very High
Sepsis 51 95.76 Very High Very High Very High
Respiratory Syncytial Virus 297 95.56 Very High Very High Very High
INFLAMMATION 84 92.08 High High
Cv Unclassified Under Development 39 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For our studies we have created a transgenic mouse line to directly test the effect of HIF-1?
Regulation (effect) of HIF-1 associated with targeted disruption
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.16 Pain Relevance 0
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Regulation (regulation) of HIF-1 associated with hypoxia
2) Confidence 0.26 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.52 Pain Relevance 0.10
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Regulation (regulation) of hypoxia-inducible factor-1 associated with hypoxia
3) Confidence 0.26 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.52 Pain Relevance 0.10
As a result, the ODD binds the Von Hippel-Lindau factor (VHL) under normoxic conditions, targeting HIF-1 for proteasomal degradation.
Regulation (targeting) of HIF-1
4) Confidence 0.20 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.73 Pain Relevance 0.12
found a role of bacterial siderophores in HIF-1?
Regulation (role) of HIF-1
5) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.85 Pain Relevance 0.08
The modification is required for the binding of the von Hippel-Lindau (VHL) tumor suppressor protein, the recognition component of an E3 ubiquitin-protein ligase that targets HIF-1?
Regulation (targets) of HIF-1 associated with cancer
6) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.62 Pain Relevance 0
This also allows us to investigate the effects of enhancing HIF-1 activity in the adult animal, avoiding any developmental effects, and modeling the potential use of HIF-1?
Spec (investigate) Regulation (effects) of HIF-1
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.49 Pain Relevance 0.05
[2] to form a dimer that binds to the hypoxia response element (HRE) in HIF-1 regulated genes [3].
Regulation (regulated) of HIF-1 associated with hypoxia
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.35 Pain Relevance 0
Therefore, we next investigated the effects of UV-inactivated virus on the HIF-1 ?
Spec (investigated) Regulation (effects) of HIF-1
9) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.14 Pain Relevance 0.05
Ascorbate is required for the optimal activity of the proline and asparagine hydroxylases that control the transcription factor HIF-1 [101].
Regulation (control) of HIF-1
10) Confidence 0.04 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.21 Pain Relevance 0.03

General Comments

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