INT153067

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 11.83
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 127 99.28 Very High Very High Very High
Pain 2 65.76 Quite High
Inflammatory response 8 61.20 Quite High
agonist 9 50.00 Quite Low
Eae 2 12.20 Low Low
COX2 42 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 178 100.00 Very High Very High Very High
Respiratory Syncytial Virus 594 99.88 Very High Very High Very High
Viral Infection 18 99.70 Very High Very High Very High
Infection 534 99.38 Very High Very High Very High
INFLAMMATION 131 99.28 Very High Very High Very High
Heterotopic Ossification 4 98.72 Very High Very High Very High
Metaplasia 4 97.56 Very High Very High Very High
Disease 138 96.24 Very High Very High Very High
Alzheimer's Dementia 5 92.88 High High
Toxicity 3 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Positive_regulation (leads) of Positive_regulation (up-regulation) of HIF-1 associated with hypoxia
1) Confidence 0.49 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.52 Pain Relevance 0.10
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Positive_regulation (leads) of Positive_regulation (up-regulation) of hypoxia-inducible factor-1 associated with hypoxia
2) Confidence 0.49 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.52 Pain Relevance 0.10
during infection with human pathogenic bacteria [54].Similarly, previous studies on viral infections with RSV have demonstrated induction of HIF-1?
Positive_regulation (demonstrated) of Positive_regulation (induction) of HIF-1 associated with viral infection, respiratory syncytial virus and infection
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.27 Pain Relevance 0
Additional studies with Y enterocolitica, S enterica subsp enterica, or E aerogenes, and, moreover, application of their siderophores (yersiniabactin, salmochelin, aerobactin) caused a robust, dose-dependent HIF-1?
Positive_regulation (caused) of Positive_regulation (caused) of HIF-1
4) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.18 Pain Relevance 0.03
B activity is required for HIF-1 protein accumulation under hypoxia [28].
Positive_regulation (required) of Positive_regulation (accumulation) of HIF-1 associated with hypoxia
5) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.02 Pain Relevance 0.16
Taken together, such studies demonstrate a role for bacterial siderophores in hypoxia-independent activation of HIF-1?
Neg (independent) Positive_regulation (independent) of Neg (independent) Positive_regulation (activation) of HIF-1 associated with hypoxia
6) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.13 Pain Relevance 0
These studies demonstrated that infection of mice with Y enterocolitica led to functional activation of HIF-1?
Positive_regulation (led) of Positive_regulation (activation) of HIF-1 associated with infection
7) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.46 Pain Relevance 0.04
While some studies have identified a host-protective role of HIF-1?
Positive_regulation (protective) of Positive_regulation (role) of HIF-1
8) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.20 Pain Relevance 0.05
In the pulmonary vascular bed, evidence has emerged for the following paradigm: increased delivery of nitrosothiols to the pulmonary vascular bed results in the activation of hypoxia related gene regulatory proteins including specificity proteins and hypoxia inducible factor-1 through S-nitrosylation reactions [11].
Positive_regulation (results) of Positive_regulation (activation) of hypoxia inducible factor-1 associated with hypoxia
9) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.76 Pain Relevance 0
protein but it did not reduce the increase of HIF-1 transcription factor induced by hypoxia [32].
Positive_regulation (increase) of Neg (not) Positive_regulation (induced) of HIF-1 associated with hypoxia
10) Confidence 0.03 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.75 Pain Relevance 0

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