INT15307

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 4.70
Pain Relevance 9.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
auditory cortex 2
spinal cord 2
FRAP 1
spines 1
neurons 1
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 110 100.00 Very High Very High Very High
substance P 17 100.00 Very High Very High Very High
electroacupuncture 15 100.00 Very High Very High Very High
Pain threshold 7 100.00 Very High Very High Very High
analgesia 4 100.00 Very High Very High Very High
agonist 181 99.92 Very High Very High Very High
Serotonin 18 99.92 Very High Very High Very High
Calcitonin gene-related peptide 36 99.48 Very High Very High Very High
ischemia 74 99.44 Very High Very High Very High
Dorsal horn 15 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 35 100.00 Very High Very High Very High
Cv Unclassified Under Development 64 99.44 Very High Very High Very High
Ganglion Cysts 10 97.44 Very High Very High Very High
Experimental Arthritis 3 97.16 Very High Very High Very High
Vasculitis 8 96.16 Very High Very High Very High
Neointima 44 94.12 High High
INFLAMMATION 32 93.04 High High
Starvation 8 91.36 High High
Injury 102 90.56 High High
Obesity 48 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
agonists in modulating the activity of mTOR have not yet been done.
Regulation (modulating) of mTOR associated with agonist
1) Confidence 0.48 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.17 Pain Relevance 0.05
As shown in Fig. 2, there was no immunoreactivity for p-mTOR in normal uninjured OLETF rats.
Neg (no) Regulation (immunoreactivity) of p-mTOR
2) Confidence 0.42 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.48 Pain Relevance 0
To confirm the inhibitory effect of various concentrations of rosiglitazone on p-mTOR, changes in p-mTOR levels were estimated by immunoblot analysis.
Regulation (changes) of p-mTOR
3) Confidence 0.42 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.09 Pain Relevance 0
[Effects of capsaicin and electroacupuncture on the fluoride resistant acid phosphatase (FRAP) and acetylcholinesterase (AChE) activities in the dorsal root ganglion (DRG) neurons of rats: a histochemical observation].
Regulation (Effects) of FRAP in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, qutenza and electroacupuncture
4) Confidence 0.30 Published 1993 Journal Zhen Ci Yan Jiu Section Title Doc Link 7923716 Disease Relevance 0.68 Pain Relevance 1.33
CONCLUSIONS: These findings shed light on the pathogenesis of splenomegaly in portal hypertension, and identify mTOR signaling as a potential target for therapeutic intervention in this disease.


Regulation (target) of mTOR
5) Confidence 0.27 Published 2010 Journal J. Hepatol. Section Body Doc Link 20206401 Disease Relevance 0 Pain Relevance 0
As expected following this, a significant reduction in antioxidant power, as indicated by FRAP value, was observed.
Regulation (value) of FRAP
6) Confidence 0.26 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.48 Pain Relevance 0.20
Modulation of FRAP value
Regulation (Modulation) of FRAP
7) Confidence 0.26 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1940022 Disease Relevance 0.48 Pain Relevance 0.20
The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control of a subset of mRNAs through regulation of its initiation step.
Regulation (target) of Rapamycin
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control of a subset of mRNAs through regulation of its initiation step.
Regulation (target) of mTOR
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
Importantly, polyribosomes and other components or regulators of the translational machinery, including mTOR and its downstream targets S6K and 4E-BP have also been reported to be present in spines and dendritic shafts [80], [81].
Regulation (regulators) of mTOR in spines
10) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
Therefore, regulation of ERK/mTOR signaling by interactions of the dopaminergic and glutamatergic systems at pre- and/or postsynaptic sites might play a role in long-term FM discrimination memory in the gerbil auditory cortex.
Spec (might) Regulation (regulation) of mTOR in auditory cortex
11) Confidence 0.25 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.25
In neurons, mTOR activity can be regulated by various extracellular stimuli, such as trophic factors, hormones, and neurotransmitters (Jaworski and Sheng 2006).
Regulation (regulated) of mTOR in neurons associated with neurotransmitter
12) Confidence 0.25 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0.23 Pain Relevance 0.47
Histochemical changes of substance P, FRAP, serotonin and succinic dehydrogenase in the spinal cord of rats with adjuvant arthritis.
Regulation (changes) of FRAP in spinal cord associated with experimental arthritis, serotonin, arthritis, spinal cord and substance p
13) Confidence 0.25 Published 1985 Journal Life Sci. Section Title Doc Link 2580206 Disease Relevance 0.40 Pain Relevance 0.62
The alterations in the Ane-AA group were accompanied by hyperphosphorylation of protein kinase B and the mammalian target of rapamycin (mTOR).
Regulation (target) of mTOR
14) Confidence 0.24 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16352675 Disease Relevance 0.09 Pain Relevance 0.33
Using western blotting and immunohistochemistry, we found that intraplantar injections of rapamycin reduced phosphorylation of downstream targets of mTOR, therefore suggesting that mTOR activity was inhibited by rapamycin.
Regulation (targets) of mTOR
15) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.09 Pain Relevance 0.08
The data presented here implies that, even in the absence of C- fibers activation, local translation of mRNA regulates the sensitivity of some A- fibers and therefore modulation of mTOR signalling can influence the response of these fibers.
Regulation (modulation) of mTOR
16) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.54
The mammalian target of rapamycin (mTOR) is an enzyme located in the non-particulate region of the cytoplasm that plays an essential role in connecting extracellular signals with intracellular pathways that regulate cell cycle and proliferation.
Regulation (target) of mTOR
17) Confidence 0.21 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.40 Pain Relevance 0.13
In conclusion, exercise improved the AMPK and mTOR responses to leptin administration and contributed to appetite-suppressive actions.
Regulation (responses) of mTOR
18) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.32 Pain Relevance 0
Whereas, low dose drug (25 mg/kg) failed to alter FRAP in both the age groups.
Neg (failed) Regulation (alter) of FRAP in FRAP
19) Confidence 0.19 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16328967 Disease Relevance 0 Pain Relevance 0.42
A similar age-dependent alteration in the density of FRAP activity was also observed.
Regulation (alteration) of FRAP
20) Confidence 0.19 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1721077 Disease Relevance 0.14 Pain Relevance 0.84

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