INT153074

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2)
kinase activity (Erbb2) cytoplasm (Erbb2)
Anatomy Link Frequency
cardiomyocytes 4
Erbb2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 95.92 Very High Very High Very High
positron emission tomography 8 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 13 97.80 Very High Very High Very High
Natriuresis 2 96.24 Very High Very High Very High
Coronary Heart Disease 2 90.24 High High
Lung Cancer 27 78.12 Quite High
Injury 2 72.04 Quite High
Stress 3 71.44 Quite High
Dilated Cardiomyopathy 2 69.64 Quite High
Cancer 39 68.68 Quite High
Apoptosis 22 65.76 Quite High
Myocardial Infarction 2 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate in this model that lapatinib-mediated blockade of both EGFR and HER-2 phosphorylation causes downstream signaling alteration upon drug administration.
Negative_regulation (blockade) of Phosphorylation (phosphorylation) of HER-2
1) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.49 Pain Relevance 0
As a result, hErbB-1-mut was expressed selectively in cardiomyocytes leading to the blockade of endogenous ErbB-1 phosphorylation and ErbB-2 transphosphorylation.
Negative_regulation (blockade) of Phosphorylation (transphosphorylation) of ErbB-2 in cardiomyocytes
2) Confidence 0.48 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18599591 Disease Relevance 0.47 Pain Relevance 0.10
As a result, hErbB-1-mut was expressed selectively in cardiomyocytes leading to the blockade of endogenous ErbB-1 phosphorylation and ErbB-2 transphosphorylation.
Negative_regulation (blockade) of Phosphorylation (phosphorylation) of ErbB-2 in cardiomyocytes
3) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18599591 Disease Relevance 0.46 Pain Relevance 0.10

General Comments

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