INT153075

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.06
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2)
kinase activity (Erbb2) cytoplasm (Erbb2)
Anatomy Link Frequency
cardiomyocytes 2
Erbb2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 5 94.72 High High
cytokine 10 5.00 Very Low Very Low Very Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 87 99.16 Very High Very High Very High
Non-small-cell Lung Cancer 13 96.76 Very High Very High Very High
Natriuresis 2 96.24 Very High Very High Very High
Coronary Heart Disease 2 90.24 High High
Cancer 103 80.76 Quite High
Lung Cancer 27 77.08 Quite High
Basal And Squamous Cell Skin Cancer 4 76.76 Quite High
Psoriasis 4 74.80 Quite High
Injury 2 70.84 Quite High
Stress 3 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate in this model that lapatinib-mediated blockade of both EGFR and HER-2 phosphorylation causes downstream signaling alteration upon drug administration.
Phosphorylation (phosphorylation) of HER-2
1) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.48 Pain Relevance 0
As a result, hErbB-1-mut was expressed selectively in cardiomyocytes leading to the blockade of endogenous ErbB-1 phosphorylation and ErbB-2 transphosphorylation.
Phosphorylation (transphosphorylation) of ErbB-2 in cardiomyocytes
2) Confidence 0.68 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18599591 Disease Relevance 0.46 Pain Relevance 0.09
As a result, hErbB-1-mut was expressed selectively in cardiomyocytes leading to the blockade of endogenous ErbB-1 phosphorylation and ErbB-2 transphosphorylation.
Phosphorylation (phosphorylation) of ErbB-2 in cardiomyocytes
3) Confidence 0.68 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18599591 Disease Relevance 0.46 Pain Relevance 0.09
Furthermore, our signaling studies revealed that EGF induced simultaneous EGF receptor phosphorylation at Tyr1173 and HER2 phosphorylation at Tyr1248 in S100A7-downregulated cell lines as compared to the vector-transfected controls.
Phosphorylation (phosphorylation) of HER2
4) Confidence 0.41 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2254193 Disease Relevance 0.51 Pain Relevance 0
In our study, phosphorylations of EGFR Tyr1173 and HER2 Tyr1248 (Figure 3A), EGFR Tyr1173 (Figure 3B), and Tyr1068 (data not shown) were reduced in S100A7-downregulated cells as compared to empty vector-transfected cell lines following treatment with increasing concentrations of EGF.
Phosphorylation (phosphorylations) of HER2
5) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox