INT15308

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Context Info
Confidence 0.81
First Reported 1985
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 29
Total Number 33
Disease Relevance 2.35
Pain Relevance 8.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
interpeduncular nucleus 7
neuronal 3
brains 2
neurons 2
spinal nerve 1
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 51 100.00 Very High Very High Very High
gABA 14 100.00 Very High Very High Very High
Glutamate 10 100.00 Very High Very High Very High
substance P 42 99.92 Very High Very High Very High
antagonist 26 99.76 Very High Very High Very High
Enkephalin 21 99.76 Very High Very High Very High
IPN 36 99.70 Very High Very High Very High
qutenza 6 99.60 Very High Very High Very High
Pain 3 99.60 Very High Very High Very High
Serotonin 9 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 97.64 Very High Very High Very High
Cirrhosis 76 95.68 Very High Very High Very High
Urological Neuroanatomy 28 89.72 High High
Nervous System Injury 4 88.64 High High
Congenital Anomalies 4 86.56 High High
Death 12 85.20 High High
Liver Disease 32 81.56 Quite High
Targeted Disruption 8 76.80 Quite High
Vomiting 17 75.68 Quite High
Syndrome 12 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pattern of ChAT localization was thus complementary to the pattern of the habenular substance P projection to the IPN.
Localization (localization) of ChAT in IPN associated with ipn and substance p
1) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445413 Disease Relevance 0 Pain Relevance 0.53
We studied the cholinergic projection to the interpeduncular nucleus (IPN) by examining localization of choline acetyltransferase (ChAT) in the habenula, fasciculus retroflexus (FR) and among the subnuclei of the IPN of the rat, using and antibody raised against ChAT.
Localization (localization) of choline acetyltransferase in IPN associated with ipn
2) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445413 Disease Relevance 0 Pain Relevance 0.44
We studied the cholinergic projection to the interpeduncular nucleus (IPN) by examining localization of choline acetyltransferase (ChAT) in the habenula, fasciculus retroflexus (FR) and among the subnuclei of the IPN of the rat, using and antibody raised against ChAT.
Localization (localization) of ChAT in IPN associated with ipn
3) Confidence 0.81 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445413 Disease Relevance 0 Pain Relevance 0.44
Although neuronal colocalization of ChAT and AChE activity is not evident in the IPN, AChE-positive neurons are in receipt of putative cholinergic, as well as peptidergic, afferent inputs.
Localization (colocalization) of ChAT in neurons associated with ipn
4) Confidence 0.79 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2337826 Disease Relevance 0 Pain Relevance 0.40
The hypothesis that glutamate corelease might account for the maintenance of the entirely synaptic ACh innervation in PF was refuted by the lack of colocalization of ChAT and vesicular glutamate transporter 2 (VGLUT2) in PF axon varicosities after dual immunolabeling.
Localization (colocalization) of ChAT associated with glutamate and increased venous pressure under development
5) Confidence 0.76 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18924144 Disease Relevance 0.33 Pain Relevance 0.33
Light and electron microscopic peroxidase-antiperoxidase immunocytochemistry has been used to localize choline acetyltransferase, substance P and enkephalin in the hypoglossal nucleus of the rat.
Localization (localize) of choline acetyltransferase in nucleus associated with enkephalin and substance p
6) Confidence 0.75 Published 1986 Journal Neuroscience Section Abstract Doc Link 2421199 Disease Relevance 0.09 Pain Relevance 0.34
A comparison of the subnuclear and ultrastructural distribution of acetylcholinesterase and choline acetyltransferase in the rat interpeduncular nucleus.
Localization (distribution) of choline acetyltransferase in interpeduncular nucleus
7) Confidence 0.74 Published 1990 Journal Brain Res. Bull. Section Title Doc Link 2337826 Disease Relevance 0 Pain Relevance 0.29
Choline acetyltransferase immunoreactivity is localized to four types of synapses in the rat interpeduncular nucleus.
Localization (localized) of Choline acetyltransferase in interpeduncular nucleus
8) Confidence 0.72 Published 1985 Journal J. Neurocytol. Section Title Doc Link 3913748 Disease Relevance 0 Pain Relevance 0.26
The normal postnatal development and response to neonatal fasciculus retroflexus (FR) lesions of serotonin, substance P (SP), and choline acetyltransferase (ChAT) distribution are described for the rat interpeduncular nucleus (IPN).
Localization (distribution) of ChAT in interpeduncular nucleus associated with ipn, serotonin and substance p
9) Confidence 0.70 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445414 Disease Relevance 0 Pain Relevance 0.57
The normal postnatal development and response to neonatal fasciculus retroflexus (FR) lesions of serotonin, substance P (SP), and choline acetyltransferase (ChAT) distribution are described for the rat interpeduncular nucleus (IPN).
Localization (distribution) of choline acetyltransferase in interpeduncular nucleus associated with ipn, serotonin and substance p
10) Confidence 0.70 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445414 Disease Relevance 0 Pain Relevance 0.57
Both cytochrome oxidase and Bodian staining paralleled the patterns of localization and development of ChAT staining.
Localization (localization) of ChAT
11) Confidence 0.70 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445414 Disease Relevance 0 Pain Relevance 0.65
RT97 expression was present in approximately 80% (+/-3.7) of surviving motoneurons at 7 dpo, and it was related to the regenerative response of motoneurons, as revealed by decreased ChAT expression and co-localization with GAP43.
Localization (localization) of ChAT in motoneurons
12) Confidence 0.68 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0.04
We investigated the effect of CRF and UcnI on colonic motor function and examined the localization of CRF, UcnI, CRF receptors, choline acetyltransferase (ChAT), and 5-HT.
Spec (examined) Localization (localization) of choline acetyltransferase
13) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.28
We investigated the effect of CRF and UcnI on colonic motor function and examined the localization of CRF, UcnI, CRF receptors, choline acetyltransferase (ChAT), and 5-HT.
Spec (examined) Localization (localization) of ChAT
14) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.31
The localizations of CRF, UcnI, CRF receptors, ChAT, and 5-HT in the colon were investigated by immunohistochemistry.
Spec (investigated) Localization (localizations) of ChAT in colon
15) Confidence 0.68 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.41
In conclusion, (1) electrically-evoked release of ACh was measured for the first time in three septal subregions; (2) the postnatal development of the presynaptic cholinergic functions: ChAT activity, ACh release and muscarinic autoreceptors occurs almost synchronously in these regions of the septal complex and parallels that in the hippocampal formation; (3) as in the hippocampus, the postnatal development of autoreceptors was delayed with respect to the exocytotic release of ACh.
Localization (release) of ChAT in hippocampal formation associated with hippocampus
16) Confidence 0.67 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10209237 Disease Relevance 0 Pain Relevance 0.19
UcnI and ChAT, as well as UcnI and 5-HT, were colocalized in some of the neuronal cells of the myenteric plexus.
Localization (colocalized) of ChAT in neuronal
17) Confidence 0.64 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.38
RESULTS: SNL did not alter spontaneous release from synaptosomes or choline acetyltransferase immunoreactivity in the spinal dorsal horn, but it reduced KCl-evoked acetylcholine release.
Localization (release) of choline acetyltransferase in dorsal horn
18) Confidence 0.63 Published 2010 Journal Anesthesiology Section Body Doc Link 20613480 Disease Relevance 0.08 Pain Relevance 0
In order to determine the different coexistence patterns of these molecules in lateral efferent perikarya, we have used double and triple immunofluorescence co-localization techniques to colocalize choline acetyltransferase, glutamate decarboxylase, tyrosine hydroxylase, calcitonin gene-related peptide and enkephalins in single sections of the lateral superior olive.
Localization (colocalize) of choline acetyltransferase in lateral associated with glutamate, enkephalin and calcitonin gene-related peptide
19) Confidence 0.63 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9058055 Disease Relevance 0 Pain Relevance 0.52
METHODS: Male rats underwent L5-L6 spinal nerve ligation (SNL), and their lumbar spinal dorsal horns with or without spinal BDNF infusion were used for either synaptosome preparation for acetylcholine release or immunostaining for choline acetyltransferase.
Localization (acetylcholine release) of choline acetyltransferase in spinal nerve
20) Confidence 0.59 Published 2010 Journal Anesthesiology Section Body Doc Link 20613480 Disease Relevance 0.09 Pain Relevance 0

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