INT153083

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 5 50.00 Quite Low
Pain 2 26.40 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Antiemetics 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 116 98.96 Very High Very High Very High
Cancer 86 97.52 Very High Very High Very High
Breast Cancer 18 65.40 Quite High
Toxicity 44 56.48 Quite High
Pancreatitis 6 50.00 Quite Low
Parkinson's Disease 1 50.00 Quite Low
Necrosis 5 47.56 Quite Low
Infection 2 33.04 Quite Low
Injury 2 32.16 Quite Low
Pain 2 26.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore any increase in bcl-2 or decrease in bax will push the balance towards chemo resistance and an increase in bax or decrease in bcl-2 will result in increased apoptosis [26-30].
Positive_regulation (increase) of Negative_regulation (decrease) of bcl-2 associated with apoptosis
1) Confidence 0.32 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.44 Pain Relevance 0
Therefore any increase in bcl-2 or decrease in bax will push the balance towards chemo resistance and an increase in bax or decrease in bcl-2 will result in increased apoptosis [26-30].
Positive_regulation (increase) of Negative_regulation (decrease) of bcl-2 associated with apoptosis
2) Confidence 0.30 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.39 Pain Relevance 0
Differential upregulation of the apoptotic mediators p53, Bax, cytochrome c, and caspase-3 and -9, and downregulation of antiapoptotic Bcl-2, was observed in CP.
Positive_regulation (upregulation) of Negative_regulation (downregulation) of Bcl-2
3) Confidence 0.30 Published 2008 Journal J. Gastroenterol. Section Body Doc Link 18600392 Disease Relevance 0.07 Pain Relevance 0

General Comments

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