INT153084

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AKR1C1) oxidoreductase activity (AKR1C1) cytoplasm (AKR1C1)
AKR1C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 1 98.52 Very High Very High Very High
Glutamate 1 87.12 High High
palliative 1 43.68 Quite Low
Analgesic 1 13.12 Low Low
aspirin 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 6 98.56 Very High Very High Very High
Dysmenorrhea 1 98.52 Very High Very High Very High
Cancer 79 94.76 High High
Recurrence 1 90.20 High High
Metastasis 6 89.28 High High
Colon Cancer 40 84.08 Quite High
Breast Cancer 24 75.00 Quite High
Carcinoma 8 52.24 Quite High
Apoptosis 11 41.80 Quite Low
Anxiety Disorder 1 13.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myometrial AKR1C1 mRNA expression was significantly greater in spontaneously laboring subjects compared with those not in labor (2.4-fold [1.97 to 2.98], P = 0.02).
Positive_regulation (Myometrial) of Gene_expression (expression) of AKR1C1 mRNA
1) Confidence 0.50 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.10 Pain Relevance 0.10
DHP requires the actions of AKR1C1-AKR1C3 (3?
Positive_regulation (requires) of Gene_expression (actions) of AKR1C1
2) Confidence 0.48 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.69 Pain Relevance 0
Previously it was also shown that gene expression of AKR1C1 could be upregulated in HT29 cells by phenolic antioxidants [42].
Positive_regulation (upregulated) of Gene_expression (expression) of AKR1C1
3) Confidence 0.30 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.18 Pain Relevance 0.04
Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of dihydrodiol dehydrogenase associated with stomach cancer
4) Confidence 0.02 Published 2009 Journal Dig. Dis. Sci. Section Title Doc Link 18600452 Disease Relevance 0.59 Pain Relevance 0

General Comments

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