INT153106

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Srr) lyase activity (Srr) aging (Srr)
plasma membrane (Srr) cellular amino acid metabolic process (Srr) cytoplasm (Srr)
Anatomy Link Frequency
brain 4
Srr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
Opioid 2 99.22 Very High Very High Very High
nMDA receptor 4 98.72 Very High Very High Very High
agonist 2 97.08 Very High Very High Very High
Hippocampus 2 60.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase.
Regulation (regulating) of Transcription (expressions) of racemase in brain associated with morphine
1) Confidence 0.37 Published 2008 Journal J. Pharmacol. Sci. Section Title Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.62
To further elucidate the mechanism underlying the activation of NMDA receptors following chronic opioid administration, we have evaluated the effects of the chronic administration of morphine on the mRNA and protein expressions of serine racemase and DAO and on the contents of D-serine in several areas of the rat brain.
Regulation (effects) of Transcription (expressions) of racemase in brain associated with nmda receptor, opioid and morphine
2) Confidence 0.37 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.63

General Comments

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