INT153111

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.41
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Srr) lyase activity (Srr) aging (Srr)
plasma membrane (Srr) cellular amino acid metabolic process (Srr) cytoplasm (Srr)
Anatomy Link Frequency
hippocampus 4
brain 2
Srr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 13 99.52 Very High Very High Very High
Morphine 5 99.28 Very High Very High Very High
Opioid 1 88.40 High High
nMDA receptor 38 87.40 High High
antagonist 12 84.92 Quite High
agonist 21 83.48 Quite High
Glutamate receptor 10 81.76 Quite High
ischemia 2 77.92 Quite High
Inflammation 18 70.88 Quite High
Glutamate 34 60.28 Quite High
Disease Link Frequency Relevance Heat
Disease 60 99.64 Very High Very High Very High
Disease Progression 2 88.80 High High
Injury 2 78.32 Quite High
Cv Unclassified Under Development 2 77.92 Quite High
Alzheimer's Dementia 12 75.00 Quite High
INFLAMMATION 18 70.88 Quite High
Drug Induced Neurotoxicity 16 21.88 Low Low
Amyloid Plaque 2 12.12 Low Low
Toxicity 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated administration of morphine for 30 days produced a significant augmentation of both the mRNA and protein expressions of serine racemase in all the brain regions, whereas no significant change in the protein expression of DAO was observed in all the brain regions.
Positive_regulation (augmentation) of Transcription (expressions) of racemase in brain associated with morphine
1) Confidence 0.41 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18603832 Disease Relevance 0 Pain Relevance 0.66
Our initial analysis here indicates that there is an elevated steady-state level of serine racemase mRNA in AD hippocampus versus age-matched controls.
Positive_regulation (elevated) of Transcription (level) of serine racemase in hippocampus associated with hippocampus and disease
2) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 1.24 Pain Relevance 0.25
Finally, the levels of serine racemase mRNA were elevated in Alzheimer's disease hippocampus, relative to age-matched controls.


Positive_regulation (elevated) of Transcription (levels) of serine racemase in hippocampus associated with hippocampus and disease
3) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Abstract Doc Link PMC483052 Disease Relevance 0.17 Pain Relevance 0.23

General Comments

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