INT153123

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.01
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (NFKBIA, RELA) cytosol (NFKBIA, RELA) nucleus (NFKBIA, RELA)
transcription factor binding (NFKBIA, RELA) nucleoplasm (RELA) aging (RELA)
NFKBIA (Homo sapiens)
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 84.24 Quite High
Inflammation 10 83.88 Quite High
Osteoarthritis 8 75.00 Quite High
Pain 2 55.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 6 93.04 High High
INFLAMMATION 10 83.88 Quite High
Osteoarthritis 8 75.00 Quite High
Arthritis 4 74.96 Quite High
Disease 6 63.32 Quite High
Pain 2 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
IkappaBalpha-phosphorylation Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of p65 subunit
1) Confidence 0.03 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.01 Pain Relevance 0.36
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
IkappaBalpha-ubiquitination Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of p65 subunit
2) Confidence 0.03 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.00 Pain Relevance 0.35

General Comments

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