INT153125

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.57
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
cleavage 10
chondrocytes 2
hepatocytes 2
MCF-7 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 43 95.64 Very High Very High Very High
Inflammation 21 91.36 High High
cINOD 9 84.00 Quite High
COX-2 inhibitor 2 81.92 Quite High
Osteoarthritis 4 76.96 Quite High
cytokine 5 75.68 Quite High
Pain 1 46.88 Quite Low
cOX1 1 25.00 Low Low
Kinase C 21 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 333 100.00 Very High Very High Very High
Cancer 134 99.28 Very High Very High Very High
Breast Cancer 10 97.48 Very High Very High Very High
Colon Cancer 44 96.04 Very High Very High Very High
Death 55 91.60 High High
INFLAMMATION 24 91.36 High High
Lung Cancer 2 87.68 High High
Osteoporosis 27 79.36 Quite High
Osteoarthritis 4 75.00 Quite High
Acute Monocytic Leukemia 1 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A pan-caspase inhibitor, z-VAD-fmk, suppressed this increase in apoptosis and also suppressed the cleavage of caspase-8, caspase-3, and PARP, suggesting a caspase-dependent mechanism.
Negative_regulation (suppressed) of Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
1) Confidence 0.32 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19360361 Disease Relevance 0.59 Pain Relevance 0.27
Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells.
Negative_regulation (suppress) of Protein_catabolism (cleavage) of PARP in MCF-7 associated with breast cancer and apoptosis
2) Confidence 0.27 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.99 Pain Relevance 0.26
Furthermore, we observed that resveratrol as well as ALLN inhibited IL-1beta-induced apoptosis, caspase-3 activation and PARP cleavage in human articular chondrocytes.
Negative_regulation (inhibited) of Protein_catabolism (cleavage) of PARP in chondrocytes associated with apoptosis
3) Confidence 0.19 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.88 Pain Relevance 0.29
In contrast, from 2 h onwards, cleavage of the PARP was reduced in U2OS-h-GAAP compared to that in U2OS-neo cells (Figure 6D).
Negative_regulation (reduced) of Protein_catabolism (cleavage) of PARP in cleavage
4) Confidence 0.15 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.53 Pain Relevance 0
Like THP1 macrophages, normal peripheral blood monocytes restored the MMP and prevented activation of caspase 8 and cleavage of PARP in TRAIL-treated tumor cells (data not shown, Figure S2), which is consistent with the ability of colon cancer cells to induce IL-1?
Negative_regulation (prevented) of Protein_catabolism (cleavage) of PARP in cleavage associated with cancer and colon cancer
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.08 Pain Relevance 0
However, taurine treatment could inhibit this NaAsO2-induced cleavage of PARP.


Negative_regulation (inhibit) of Protein_catabolism (cleavage) of PARP in cleavage
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.77 Pain Relevance 0
Prior treatment of natansnin profoundly decreased the increased expression of caspase- 3, PARP cleavage and translocation of cytochrome C from mitochondria to cytosol indicating that natansnin decreases the apoptosis in hepatocytes.
Negative_regulation (decreased) of Protein_catabolism (cleavage) of PARP in hepatocytes associated with apoptosis
7) Confidence 0.03 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.68 Pain Relevance 0
Vanadate also prevented GC-induced poly-ADP-ribose polymerase cleavage.
Negative_regulation (prevented) of Protein_catabolism (cleavage) of poly-ADP-ribose polymerase in cleavage
8) Confidence 0.02 Published 2007 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2173947 Disease Relevance 1.05 Pain Relevance 0.16

General Comments

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