INT153137

Context Info Confidence 0.18 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.89 Pain Relevance 0.26

chromosome (ESCO2) nucleus (ESCO2) transferase activity, transferring acyl groups (ESCO2) cell cycle (ESCO2)

Anatomy Link Frequency external 1 ESCO2 (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 37 91.36 Nav1.6 14 67.36 Pain 4 25.00 hyperexcitability 1 13.96 Spinal cord 12 5.00 Kinase C 2 5.00 antagonist 2 5.00 Neuronal excitability 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 6 94.56 Injury 2 94.24 Targeted Disruption 7 90.56 Glioma 1 82.36 Cancer 2 81.16 Convulsion 4 37.24 Epilepsy 1 34.84 Cretinism 1 32.36 Congenital Anomalies 1 16.28 Nervous System Malformation 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ANOVA results indicated significant increases in memory complaints across increasing RBS score ranges with large effect sizes.

Positive_regulation (increasing) of RBS

1) Confidence 0.18 Published 2008 Journal Clin Neuropsychol Section Abstract Doc Link 18609315 Disease Relevance 0.25 Pain Relevance 0

These findings suggest that elevated scores on the RBS are associated with over-reporting of memory problems, which provides further external validation of the RBS as a sensitive measure of cognitive response bias.

Positive_regulation (elevated) of RBS in external associated with cognitive disorder

2) Confidence 0.12 Published 2008 Journal Clin Neuropsychol Section Abstract Doc Link 18609315 Disease Relevance 0.31 Pain Relevance 0

First, in RBs, T4 rapidly increased sodium current amplitudes at 48 but not 24 hpf, consistent with detection of ?

Positive_regulation (increased) of RBs

3) Confidence 0.01 Published 2009 Journal Neural Dev Section Body Doc Link PMC2704202 Disease Relevance 0.33 Pain Relevance 0.26

General Comments

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