INT153156

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 7.88
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLKB1) extracellular space (KLKB1) extracellular region (KLKB1)
plasma membrane (KLKB1)
Anatomy Link Frequency
plasma 12
KLKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 140 97.68 Very High Very High Very High
b2 receptor 64 88.72 High High
Inflammation 3 88.36 High High
Pain 34 87.32 High High
antagonist 35 5.00 Very Low Very Low Very Low
B1 receptor 16 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Edema 408 99.40 Very High Very High Very High
Hereditary Angioedema 730 99.12 Very High Very High Very High
Sprains And Strains 10 98.68 Very High Very High Very High
Pressure Volume 2 Under Development 10 97.36 Very High Very High Very High
Anaphylaxis 32 96.88 Very High Very High Very High
Pain 34 93.52 High High
INFLAMMATION 3 92.80 High High
Suicidal Behaviour 1 83.32 Quite High
Injury 17 70.40 Quite High
Breast Cancer 3 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery.
Negative_regulation (inhibitor) of plasma kallikrein in plasma associated with pressure volume 2 under development and hereditary angioedema
1) Confidence 0.48 Published 2008 Journal Expert Opin Biol Ther Section Title Doc Link 18613770 Disease Relevance 0.20 Pain Relevance 0.22
OBJECTIVE: Ecallantide (DX-88) is a potent and specific inhibitor of plasma kallikrein.
Negative_regulation (inhibitor) of plasma kallikrein in plasma
2) Confidence 0.48 Published 2008 Journal Expert Opin Biol Ther Section Body Doc Link 18613770 Disease Relevance 0.19 Pain Relevance 0
PCI is a multifunctional serpin that can act both as a protease inhibitor of the coagulation (activated protein C, factor Xa, factor XIa, protein Z-dependent protease inhibitor and plasma kallikrein), the fibrinolytic (urokinase-type plasminogen activator (uPA) and tissue-type PA (tPA)), and the fertilization system (acrosin and prostate specific antigen) (Christensson and Lilja 1994; Ecke et al. 1992; Espana et al. 1989; Geiger et al. 1989; Marlar and Griffin 1980; Meijers et al. 1988; Suzuki et al. 1983; Zheng et al. 1994).
Negative_regulation (inhibitor) of plasma kallikrein in plasma
3) Confidence 0.42 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.21 Pain Relevance 0
The first plasma kallikrein inhibitor, other than C1INH, to be used for the treatment of HAE was aprotinin (Trasylol®).
Negative_regulation (inhibitor) of plasma kallikrein in plasma associated with hereditary angioedema
4) Confidence 0.07 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 1.01 Pain Relevance 0.27
More recently, a specific plasma kallikrein inhibitor, ecallantide, has been developed.
Negative_regulation (inhibitor) of plasma kallikrein in plasma
5) Confidence 0.07 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.80 Pain Relevance 0.16
Ecallantide (Kalbitor, Dyax Inc.) is a novel, potent and specific plasma kallikrein inhibitor produced in the Pichia pastoris strain of yeast that was identified using phage display technology for a library of rationally designed variants of the first Kunitz domain of human lipoprotein-associated coagulation inhibitor (LACI) [62,63].
Negative_regulation (inhibitor) of plasma kallikrein in plasma associated with sprains and strains
6) Confidence 0.07 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.83 Pain Relevance 0.12
Replacement therapy with C1INH will inhibit both plasma kallikrein and activated factor XII.
Negative_regulation (inhibit) of plasma kallikrein in plasma
7) Confidence 0.07 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 1.02 Pain Relevance 0.30
Inhibition of plasma kallikrein using other non-C1INH drugs is another strategy that has been used.
Negative_regulation (Inhibition) of plasma kallikrein in plasma
8) Confidence 0.07 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 1.01 Pain Relevance 0.28
Two of these medications are C1INH concentrates and the third is a plasma kallikrein inhibitor.
Negative_regulation (inhibitor) of plasma kallikrein in plasma
9) Confidence 0.07 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.90 Pain Relevance 0
This protein is a broad-spectrum Kunitz-type serpin inhibitor with activity against trypsin, plasmin and plasma kallikrein.
Negative_regulation (inhibitor) of plasma kallikrein in plasma
10) Confidence 0.05 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.92 Pain Relevance 0.24
Plasma kallikrein inhibitor: ecallantide
Negative_regulation (inhibitor) of Plasma kallikrein in Plasma
11) Confidence 0.05 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.81 Pain Relevance 0
Increasing direct clearance from blood (kCL) drastically lowered free VEGF and sVEGFR1 concentrations in plasma (Fig. 10).
Negative_regulation (lowered) of plasma in plasma
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox