INT153157

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
output neurons 2
neurons 2
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 23 100.00 Very High Very High Very High
Nucleus accumbens 11 96.72 Very High Very High Very High
Morphine 5 92.68 High High
cocaine 5 76.80 Quite High
antagonist 2 34.16 Quite Low
agonist 3 30.88 Quite Low
Enkephalin 5 5.00 Very Low Very Low Very Low
substance P 5 5.00 Very Low Very Low Very Low
GABAergic 4 5.00 Very Low Very Low Very Low
Dynorphin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 13 99.08 Very High Very High Very High
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The generation of BAC transgenic mice expressing DARPP-32 with different tags under the control of drd1a and drd2 promoters allowed the analysis of DARPP-32 phosphorylation selectively in the two populations of striatal output neurons in vivo (Bateup et al., 2008) (Figure 1).
Regulation (under) of Regulation (control) of drd1a in output neurons associated with targeted disruption
1) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.10 Pain Relevance 0.07
Using transgenic mice with enhanced green fluorescent protein (EGFP) expression under the control of the dopamine D1 receptor (D1R) (Drd1a-EGFP) or D2 receptor promoter (Drd2-EGFP) we show that context-dependent ERK phosphorylation is restricted to D1R-expressing medium spiny neurons.
Regulation (under) of Regulation (control) of dopamine D1 receptor in neurons associated with targeted disruption and dopamine
2) Confidence 0.23 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18614186 Disease Relevance 0.10 Pain Relevance 0.59

General Comments

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