INT153173

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1f) signal transducer activity (Htr1f)
Htr1f (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 5 100.00 Very High Very High Very High
Periaqueductal grey 55 96.76 Very High Very High Very High
GABAergic 27 77.76 Quite High
spastic colon 2 75.00 Quite High
Sumatriptan 43 74.24 Quite High
Raphe 3 66.64 Quite High
antagonist 13 62.72 Quite High
midbrain 9 50.00 Quite Low
agonist 14 48.72 Quite Low
Ventral tegmentum 1 31.44 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 55 96.76 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 96.00 Very High Very High Very High
Functional Bowel Disorder 2 75.00 Quite High
Diarrhoea 2 75.00 Quite High
Headache 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Photophobia 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the lack of 5-HT1F mediated inhibition is not consistent with the detection of mRNA for 5-HT1F receptors in the present study, very low levels of 5-HT1F mRNA have been reported in guinea pig [25].
Negative_regulation (inhibition) of 5-HT1F
1) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.28 Pain Relevance 0.53
This is the first example indicating micro RNA-related expression regulation of a serotonin receptor gene with a cis-regulatory variant affecting this regulation and appearing to be associated with female IBS-D.
Negative_regulation (regulation) of serotonin receptor gene associated with serotonin
2) Confidence 0.01 Published 2008 Journal Hum. Mol. Genet. Section Abstract Doc Link 18614545 Disease Relevance 0.26 Pain Relevance 0.25

General Comments

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