INT153189

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 25
Disease Relevance 14.37
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sema3a) extracellular region (Sema3a)
Anatomy Link Frequency
nerve 3
patterning 3
neurons 2
sympathetic 2
dendritic cells 1
Sema3a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 296 99.34 Very High Very High Very High
ischemia 15 98.88 Very High Very High Very High
Inflammation 51 98.70 Very High Very High Very High
bDMF 147 98.56 Very High Very High Very High
Pain 15 97.90 Very High Very High Very High
antagonist 14 97.36 Very High Very High Very High
Nerve growth factor 381 96.80 Very High Very High Very High
diabetic neuropathy 5 96.28 Very High Very High Very High
qutenza 21 94.98 High High
Antinociceptive 7 90.00 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 17 99.72 Very High Very High Very High
Sudden Death 2 99.48 Very High Very High Very High
Myocardial Infarction 14 99.44 Very High Very High Very High
Ganglion Cysts 436 99.34 Very High Very High Very High
Eczema 765 99.32 Very High Very High Very High
Coronary Artery Disease 15 98.88 Very High Very High Very High
INFLAMMATION 36 98.70 Very High Very High Very High
Acanthosis 14 98.32 Very High Very High Very High
Pruritus 170 96.96 Very High Very High Very High
Diabetic Neuropathy 5 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, Sema3a, which is a neural chemorepellent, is expressed strongly in the trabecular layer in early stage embryos and at a lower level after birth, leading to epicardial-to-endocardial transmural sympathetic innervation patterning.
Gene_expression (expressed) of Sema3a in sympathetic
1) Confidence 0.75 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18673222 Disease Relevance 1.21 Pain Relevance 0.41
Both Sema3a-deficient and Sema3a-overexpressing mice showed sudden death or lethal arrhythmias due to disruption of innervation patterning.
Gene_expression (overexpressing) of Sema3a in patterning associated with sudden death
2) Confidence 0.75 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18673222 Disease Relevance 1.12 Pain Relevance 0.39
Both Sema3a-targeted and Sema3a-overexpressing mice display sudden cardiac death or lethal arrhythmias due to disruption of innervation patterning.
Gene_expression (overexpressing) of Sema3a in patterning associated with myocardial infarction
3) Confidence 0.74 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 0.94 Pain Relevance 0.39
By comparison, the neural chemorepellent Sema3a is expressed at high levels in the subendocardium in the early stage of embryogenesis and is downregulated as development progresses, leading to epicardial-to-endocardial transmural sympathetic innervation patterning.
Gene_expression (expressed) of Sema3a in sympathetic
4) Confidence 0.74 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 0.97 Pain Relevance 0.40
Both Sema3a-targeted and Sema3a-overexpressing mice display sudden cardiac death or lethal arrhythmias due to disruption of innervation patterning.
Gene_expression (overexpressing) of Sema3a-targeted in patterning associated with myocardial infarction
5) Confidence 0.74 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 0.95 Pain Relevance 0.39
Therefore, Sema3A is expected to become an effective and useful drug for AD patients with severe recalcitrant itching, which is resistant to anti-histamine drugs of H1-blocker and anti-inflammatory steroid ointment.
Gene_expression (expected) of Sema3A associated with inflammation, pruritus and eczema
6) Confidence 0.60 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.17 Pain Relevance 0.33
Histological examinations revealed a decrease in: (a) epidermal thickness; (b) the density of invasive nerve fibers in the epidermis; (c) inflammatory infiltrates, including mast cells and CD4+ T cells; and (d) the production of IL-4 in the Sema3A-treated lesions.
Gene_expression (production) of Sema3A in epidermis associated with inflammation
7) Confidence 0.59 Published 2008 Journal J. Invest. Dermatol. Section Abstract Doc Link 18615113 Disease Relevance 0.96 Pain Relevance 0.15
Sema3A is expressed in developing tongue [76] and appears to be important during both trigeminal and chorda tympani axon guidance [70,72].
Gene_expression (expressed) of Sema3A in tongue
8) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.15 Pain Relevance 0.03
In addition, Sema3A and NRP-1 of its receptors expressed in human keratinocytes52 may be relevant to the above-mentioned suppressive effect of Sema3A on acanthosis observed in our present experiment.
Gene_expression (expressed) of Sema3A associated with acanthosis
9) Confidence 0.53 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.49 Pain Relevance 0.06
Also Sema3A and NRP-1 of its receptors expressed in dendritic cells and T cells53,54 may be relevant to the immunological effect of Sema3A such as suppression of CD4+ T cells infiltration and IL-4 production observed in the AD-like lesions in NC/Nga mice treated with Sema3A, as above-mentioned.
Gene_expression (expressed) of Sema3A in T cells associated with eczema
10) Confidence 0.53 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.40 Pain Relevance 0.07
However, the most notorious clinical limitation of capsaicin application is supposed to be acute excitation of the sensory C-afferents, which is induced by the TRPV1 and results in a remarkable "hot painful burning" sensation.36 Does reduction in innervation density of intraepidermal nerve fibers by the local application of Sema3A cause such a sensation?
Gene_expression (application) of Sema3A in nerve associated with pain and qutenza
11) Confidence 0.52 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.76 Pain Relevance 0.52
Also Sema3A and NRP-1 of its receptors expressed in dendritic cells and T cells53,54 may be relevant to the immunological effect of Sema3A such as suppression of CD4+ T cells infiltration and IL-4 production observed in the AD-like lesions in NC/Nga mice treated with Sema3A, as above-mentioned.
Gene_expression (production) of Sema3A in dendritic cells associated with eczema
12) Confidence 0.52 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.47 Pain Relevance 0.14
Recently, there has been an interesting report that epidermal Sema3A levels were decreased in patients with AD compared with healthy volunteers, concomitant with the increase of epidermal nerve densities.35 This result shows that there is a good correlation between epidermal innervation and Sema3A levels, which may provide an important evidence for the therapeutic claim against itching.
Gene_expression (levels) of Sema3A in nerve associated with pruritus and eczema
13) Confidence 0.52 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.14 Pain Relevance 0.15
Recently, there has been an interesting report that epidermal Sema3A levels were decreased in patients with AD compared with healthy volunteers, concomitant with the increase of epidermal nerve densities.35 This result shows that there is a good correlation between epidermal innervation and Sema3A levels, which may provide an important evidence for the therapeutic claim against itching.
Gene_expression (levels) of Sema3A in nerve associated with pruritus and eczema
14) Confidence 0.52 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.15 Pain Relevance 0.03
Sema3A expression decreases from the medial to lateral tongue surface and prevents premature and aberrant growth of trigeminal and gustatory fibers into the tongue mid-region.
Gene_expression (expression) of Sema3A in medial
15) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.14 Pain Relevance 0
A third series of experiments were designed to further examine the involvement of Fer in the opposing NGF and Sema3A responses (Fig. 7C).
Gene_expression (responses) of Sema3A
16) Confidence 0.49 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.13 Pain Relevance 0.03
A statistically significant defect in the Sema3A response of Fps-deficient DRGs was also detected, but only under conditions were NGF was depleted prior to addition of Sema3A (Figure 7F).
Gene_expression (response) of Sema3A
17) Confidence 0.49 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.20 Pain Relevance 0.12
BDNF may act similarly by reducing the sensitivity of geniculate neurons to Sema3A inhibition, although it has not been shown to inhibit responses to Sema3A in culture [78].


Neg (inhibition) Gene_expression (inhibition) of Sema3A in neurons associated with bdmf
18) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.09 Pain Relevance 0.13
Fps-deficient DRG neurons displayed only a subtle defect in the Sema3A-induced axon retraction response
Gene_expression (defect) of Sema3A in neurons associated with dorsal root ganglion
19) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.46 Pain Relevance 0.09
The observed axon regrowth in ferDR/DR DRGs suggested that an NGF-induced outgrowth response might be competing with the Sema3A-induced retraction signal in the first 80 minutes, and that NGF response might completely overcome the Sema3A response after 80 minutes.
Gene_expression (competing) of Sema3A
20) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.26 Pain Relevance 0.10

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