INT153190

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 7.94
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sema3a) extracellular region (Sema3a)
Anatomy Link Frequency
sensory neurons 3
neurite 2
nerve 1
neurons 1
sympathetic 1
Sema3a (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 11 95.52 Very High Very High Very High
Nerve growth factor 151 92.56 High High
Antihistamine 8 87.88 High High
diabetic neuropathy 1 85.76 High High
ischemia 3 79.68 Quite High
dorsal root ganglion 111 79.64 Quite High
Pain 4 76.20 Quite High
Inflammation 25 65.04 Quite High
vanilloid receptor subtype 1 3 42.64 Quite Low
qutenza 9 39.36 Quite Low
Disease Link Frequency Relevance Heat
Shock 69 100.00 Very High Very High Very High
Disease 14 99.92 Very High Very High Very High
Eczema 342 99.28 Very High Very High Very High
Hypersensitivity 14 98.08 Very High Very High Very High
Pruritus 76 94.28 High High
Recurrence 3 87.40 High High
Diabetic Neuropathy 1 85.76 High High
Erythema 9 82.28 Quite High
Coronary Artery Disease 3 80.56 Quite High
Diabetes Mellitus 3 80.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By comparison, the neural chemorepellent Sema3a is expressed at high levels in the subendocardium in the early stage of embryogenesis and is downregulated as development progresses, leading to epicardial-to-endocardial transmural sympathetic innervation patterning.
Negative_regulation (downregulated) of Sema3a in sympathetic
1) Confidence 0.56 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 1.00 Pain Relevance 0.41
Semaphorin 3A (Sema3A), an axon guidance molecule, is a potent inhibitor of neurite outgrowth of sensory neurons.
Negative_regulation (inhibitor) of Semaphorin 3A in neurite
2) Confidence 0.38 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 1.14 Pain Relevance 0.34
Semaphorin 3A (Sema3A), an axon guidance molecule, is a potent inhibitor of neurite outgrowth of sensory neurons.
Negative_regulation (inhibitor) of Sema3A in neurite
3) Confidence 0.38 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 1.14 Pain Relevance 0.34
Semaphorin3A (Sema3A), an axon guidance molecule, is a potent inhibitor of neurite outgrowth of sensory neurons.
Negative_regulation (inhibitor) of Sema3A in sensory neurons
4) Confidence 0.37 Published 2008 Journal J. Invest. Dermatol. Section Abstract Doc Link 18615113 Disease Relevance 0.93 Pain Relevance 0.17
Semaphorin3A (Sema3A), an axon guidance molecule, is a potent inhibitor of neurite outgrowth of sensory neurons.
Negative_regulation (inhibitor) of Semaphorin3A in sensory neurons
5) Confidence 0.37 Published 2008 Journal J. Invest. Dermatol. Section Abstract Doc Link 18615113 Disease Relevance 0.94 Pain Relevance 0.17
Recently, there has been an interesting report that epidermal Sema3A levels were decreased in patients with AD compared with healthy volunteers, concomitant with the increase of epidermal nerve densities.35 This result shows that there is a good correlation between epidermal innervation and Sema3A levels, which may provide an important evidence for the therapeutic claim against itching.
Negative_regulation (decreased) of Sema3A in nerve associated with pruritus and eczema
6) Confidence 0.33 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.15 Pain Relevance 0.03
Fer-deficient neurons were also defective in Sema3A-induced axon retraction in the absence of NGF.
Negative_regulation (defective) of Sema3A in neurons
7) Confidence 0.31 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.52 Pain Relevance 0.06
Perhaps more surprising, after 80 minutes ferDR/DR axons began to grow again in the presence of Sem3A (Fig. 6B; Fig. 7; Additional file 2).
Negative_regulation (presence) of Sem3A
8) Confidence 0.31 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.27 Pain Relevance 0.10
Similarly, Dontchev et al. found that the Sema3A-induced collapse of growth cones of NGF-responsive embryonic sensory neurons was inhibited by NGF in a dose-dependent manner [49].
Negative_regulation (inhibited) of Sema3A in sensory neurons associated with shock
9) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.85 Pain Relevance 0.14

General Comments

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