INT153201

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.37
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
molecular_function (Col1a1) cytoplasm (Col1a1)
Anatomy Link Frequency
kidney 4
platelet 2
Col1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 100.00 Very High Very High Very High
fibrosis 203 99.90 Very High Very High Very High
Inflammation 121 95.44 Very High Very High Very High
antagonist 6 88.80 High High
anesthesia 3 81.28 Quite High
Angina 1 67.88 Quite High
Bile 4 50.88 Quite High
cytokine 36 37.96 Quite Low
rheumatoid arthritis 7 20.08 Low Low
Osteoarthritis 1 18.88 Low Low
Disease Link Frequency Relevance Heat
Fibrosis 211 100.00 Very High Very High Very High
Proteinuria 20 99.36 Very High Very High Very High
Hypertrophy 1 97.60 Very High Very High Very High
INFLAMMATION 125 95.44 Very High Very High Very High
Renal Disease 35 94.36 High High
Nephritis 4 90.00 High High
Necrosis 5 89.00 High High
Intervertebral Disk Degeneration 39 88.96 High High
Infection 2 87.16 High High
Chronic Hepatitis 2 86.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of type I collagen, osteocalcin and MMPs 2 and 13 increased toward week 2 and decreased thereafter, whereas the expression of MMP 8 was the highest on day 1.
Negative_regulation (decreased) of Gene_expression (expression) of type I collagen associated with metalloproteinase
1) Confidence 0.38 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.37
Nicorandil significantly prevented the overexpression of type I collagen, fibronectin, transforming growth factor (TGF)-beta, and platelet-derived growth factor (PDGF) mRNA.
Negative_regulation (prevented) of Gene_expression (overexpression) of type I collagen in platelet
2) Confidence 0.25 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19721333 Disease Relevance 1.18 Pain Relevance 0.07
The combination of both agents produced an improvement in adsorption droplets and proteinuria in the glomeruli, and cortical collagen I mRNA expression was also significantly decreased.
Negative_regulation (decreased) of Gene_expression (expression) of collagen I mRNA associated with proteinuria
3) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.86 Pain Relevance 0.17
Fibrosis was reduced in 30% of patients by the end of the 12-month treatment, and mRNAs coding for profibrogenic molecules such as COL1A1, TGF-?
Negative_regulation (reduced) of Gene_expression (molecules) of COL1A1 associated with fibrosis
4) Confidence 0.24 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.67 Pain Relevance 0.35
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Negative_regulation (level) of Gene_expression (expression) of COLIA1
5) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.70 Pain Relevance 0
The expression of type I collagen was reduced by roughly 30% in the presence of 0.5 mM NIM811 (Fig. 3A).
Negative_regulation (reduced) of Gene_expression (expression) of type I collagen
6) Confidence 0.04 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.07 Pain Relevance 0.09
It is important to highlight, however, that late treatment with Hemin was able to reduce the expression and production of pro-fibrotic molecules, as well as type I collagen and FSP-1 deposition on the injured kidney.
Negative_regulation (reduce) of Gene_expression (expression) of type I collagen in kidney associated with fibrosis
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.95 Pain Relevance 0.23
It is important to highlight, however, that late treatment with Hemin was able to reduce the expression and production of pro-fibrotic molecules, as well as type I collagen and FSP-1 deposition on the injured kidney.
Negative_regulation (reduce) of Gene_expression (production) of type I collagen in kidney associated with fibrosis
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.95 Pain Relevance 0.23

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