INT153207

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 5
Disease Relevance 0.39
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Elk1)
Elk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 12 98.16 Very High Very High Very High
Opioid 6 95.16 Very High Very High Very High
addiction 2 93.76 High High
opioid receptor 6 83.16 Quite High
withdrawal 4 75.88 Quite High
antagonist 2 74.28 Quite High
narcan 2 73.76 Quite High
Glutamate receptor 6 37.60 Quite Low
medulla 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 57 78.24 Quite High
Intrauterine Growth Retardation 3 59.84 Quite High
Pressure Volume 2 Under Development 6 58.76 Quite High
Diabetes Mellitus 3 39.28 Quite Low
Aging 6 34.80 Quite Low
Stress 12 33.36 Quite Low
Insulin Resistance 3 20.20 Low Low
Targeted Disruption 3 18.08 Low Low
Body Weight 12 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SHR suggests that untreated SHR have enhanced Elk-1 driven gene transcription at 2 days and 2 weeks.
Transcription (transcription) of Elk-1
1) Confidence 0.24 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.25 Pain Relevance 0
SHR suggests that SHR have enhanced Elk-1 driven gene transcription as compared to WKY at 2 days and 2 weeks.
Transcription (transcription) of Elk-1
2) Confidence 0.23 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0 Pain Relevance 0
TFBS analysis suggests less Elk-1-driven gene transcription in both WKY and SHR+ATCE vs.
Transcription (transcription) of Elk-1
3) Confidence 0.18 Published 2009 Journal Pflugers Arch Section Abstract Doc Link PMC2691531 Disease Relevance 0.14 Pain Relevance 0
Regulation of ERK1/2 phosphorylation by acute and chronic morphine - implications for the role of cAMP-responsive element binding factor (CREB)-dependent and Ets-like protein-1 (Elk-1)-dependent transcription; small interfering RNA-based strategy.
Transcription (transcription) of Ets-like protein-1 associated with morphine
4) Confidence 0.17 Published 2008 Journal FEBS J. Section Title Doc Link 18616461 Disease Relevance 0 Pain Relevance 0.87
Regulation of ERK1/2 phosphorylation by acute and chronic morphine - implications for the role of cAMP-responsive element binding factor (CREB)-dependent and Ets-like protein-1 (Elk-1)-dependent transcription; small interfering RNA-based strategy.
Transcription (transcription) of Elk-1 associated with morphine
5) Confidence 0.17 Published 2008 Journal FEBS J. Section Title Doc Link 18616461 Disease Relevance 0 Pain Relevance 0.87

General Comments

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