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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.16
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Rela) DNA binding (Rela) protein complex (Rela)
response to stress (Rela) cytoplasm (Rela) cytosol (Rela)
Anatomy Link Frequency
spinal 1
liver 1
dorsal horn 1
Rela (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 18 99.90 Very High Very High Very High
COX2 22 99.08 Very High Very High Very High
Dorsal horn 4 98.92 Very High Very High Very High
hyperexcitability 8 97.20 Very High Very High Very High
chemokine 3 95.28 Very High Very High Very High
allodynia 11 94.24 High High
c fibre 2 92.64 High High
Spinal cord 7 89.80 High High
withdrawal 2 85.04 High High
intrathecal 2 83.52 Quite High
Disease Link Frequency Relevance Heat
Adhesions 6 97.32 Very High Very High Very High
Neuropathic Pain 11 94.24 High High
Adenovirus Infection 7 90.84 High High
Encephalitis 1 88.24 High High
Obesity 38 86.00 High High
Cardiovascular Disease 3 78.72 Quite High
Liver Disease 3 76.56 Quite High
Appetite Loss 3 76.16 Quite High
Neurological Disease 1 66.32 Quite High
Demyelinating Disease 1 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the effect of 5th and 6th lumbar nerve (L5/L6) spinal nerve ligation (SNL) on activated nuclear factor kappaB (NFkBa) in nuclear extracts from the lumbar dorsal horn of the rat, and its relationship to prostaglandin (PG)-dependent spinal hyperexcitability and allodynia 3 days later.
Positive_regulation (activated) of NFkBa in spinal associated with allodynia, spinal nerve ligature, dorsal horn and hyperexcitability
1) Confidence 0.16 Published 2008 Journal Neuroscience Section Abstract Doc Link 18617333 Disease Relevance 0.24 Pain Relevance 0.93
This was preceded by an increase in NFkBa in the ipsilateral lumbar dorsal horn at 12 h which was still present 3 days after SNL.
Positive_regulation (increase) of NFkBa in dorsal horn associated with spinal nerve ligature and dorsal horn
2) Confidence 0.14 Published 2008 Journal Neuroscience Section Abstract Doc Link 18617333 Disease Relevance 0.31 Pain Relevance 1.31
The small heterodimer partner (SHP), an orphan nuclear receptor specifically expressed in the liver and a limited number of other tissues, is a transcriptional co-activator of NFKB and is also activated by JNK [44,45].
Positive_regulation (activator) of NFKB in liver
3) Confidence 0.09 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.29 Pain Relevance 0.03
These kinases and activated NFkB are known inducers of COX2 expression [25].
Positive_regulation (activated) of NFkB associated with cox2
4) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0.30 Pain Relevance 0.38
Moreover, this adipokine elicits the activation of NFkB [18], a transcription factor that initiates the synthesis of cell adhesion glycoprotein molecules (e.g., ICAM-1) and chemokines (e.g., MCP-1).
Positive_regulation (activation) of NFkB associated with chemokine and adhesions
5) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 1.04 Pain Relevance 0.08

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