INT153233

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.10
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (Ids)
Anatomy Link Frequency
brain 2
urine 1
Ids (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 114 62.40 Quite High
Thalamus 18 61.12 Quite High
cerebral cortex 4 60.32 Quite High
Spinal cord 7 34.88 Quite Low
carpal tunnel syndrome 4 25.20 Quite Low
Antihistamine 12 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Neurobehavioral 8 5.00 Very Low Very Low Very Low
intrathecal 6 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lysosomal Storage Diseases 21 99.78 Very High Very High Very High
Mucopolysaccharidoses 22 98.62 Very High Very High Very High
Disease 98 98.16 Very High Very High Very High
Mucopolysaccharidosis Ii 15 97.78 Very High Very High Very High
Congenital Anomalies 8 93.20 High High
Death 17 90.88 High High
Targeted Disruption 6 85.68 High High
Facies 1 79.76 Quite High
Airway Obstruction 6 46.48 Quite Low
Apoptosis 8 44.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MPS II is a heterogeneous, progressive lysosomal storage disease that results from deficiency of the enzyme, iduronate-2-sulfatase, which cleaves an O-linked sulfate from dermatan sulfate and heparan sulfate (Neufeld and Muenzer 2001).
Negative_regulation (deficiency) of iduronate-2-sulfatase associated with lysosomal storage diseases
1) Confidence 0.40 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.75 Pain Relevance 0.06
Review of the use of idursulfase in the treatment of mucopolysaccharidosis II

Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is a heterogeneous, progressive X-linked recessively inherited lysosomal storage disease that is caused by a deficiency of the enzyme iduronate-2-sulfatase, resulting in abnormal tissue accumulation of the glycosaminoglycans, dermatan sulfate and heparan sulfate.

Negative_regulation (deficiency) of iduronate-2-sulfatase associated with mucopolysaccharidoses, mucopolysaccharidosis ii and lysosomal storage diseases
2) Confidence 0.40 Published 2008 Journal Biologics : Targets & Therapy Section Title Doc Link PMC2721351 Disease Relevance 0.39 Pain Relevance 0
Group A showed brain IDS activities that decreased in parallel with the concentrations of IDS injected.
Negative_regulation (decreased) of IDS in brain
3) Confidence 0.38 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2989894 Disease Relevance 0 Pain Relevance 0
These data show that the IDS activity remains in the brain and the tissues for a long time at sufficient levels to maintain the clearance of GAG accumulation.
Negative_regulation (remains) of IDS in brain
4) Confidence 0.37 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2989894 Disease Relevance 0 Pain Relevance 0.06
Affected mice exhibit many of the features observed in humans, including elevated urine glycosaminoglycan excretion, accumulation of glycosaminoglycans in tissues and organs, and deficient iduronate-2-sulfatase enzyme activity.
Negative_regulation (deficient) of iduronate-2-sulfatase in urine
5) Confidence 0.35 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.42 Pain Relevance 0
Hunter disease (mucopolysaccharidosis type II, MPS II) is an X-linked lysosomal storage disease caused by deficiency of iduronate-2-sulfatase.
Negative_regulation (deficiency) of iduronate-2-sulfatase associated with mucopolysaccharidoses, lysosomal storage diseases and disease
6) Confidence 0.09 Published 2008 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 18618289 Disease Relevance 0.54 Pain Relevance 0

General Comments

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