INT153257

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 5.92
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1) extracellular region (Ptch1) plasma membrane (Ptch1)
Anatomy Link Frequency
cornea 2
Mes5 1
Parathyroid 1
Ptch1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 26 98.58 Very High Very High Very High
Potency 1 98.00 Very High Very High Very High
trigeminal ganglion 5 97.72 Very High Very High Very High
nociceptor 3 93.28 High High
Nerve growth factor 1 92.92 High High
Calcitonin gene-related peptide 1 91.44 High High
tolerance 12 83.24 Quite High
antagonist 1 69.84 Quite High
Neurotransmitter 2 25.20 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Shock 184 100.00 Very High Very High Very High
Wound Healing 10 99.68 Very High Very High Very High
Hypoxia 4 97.84 Very High Very High Very High
Ganglion Cysts 5 97.72 Very High Very High Very High
Death 5 97.48 Very High Very High Very High
Retinal Neovascularization 4 97.40 Very High Very High Very High
Disease 17 96.84 Very High Very High Very High
Obesity 20 94.64 High High
Insulin Resistance 50 93.68 High High
Chondroma 41 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this was not a complete loss of function, suggesting that these mutations may affect the interaction with the receptor PTCH1 or its partners, with an impact on the induction potency.
Regulation (affect) of PTCH1 associated with potency
1) Confidence 0.36 Published 2010 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 20024692 Disease Relevance 0.08 Pain Relevance 0.08
A submicroscopic deletion as small as 165 kb was detected affecting only PTCH1, whereas the other two deletions were much larger (5 and 11 Mb) [138].


Regulation (affecting) of PTCH1
2) Confidence 0.26 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.44 Pain Relevance 0
Shh did not affect the expression levels of angiogenic cytokines in cultured cell types. mRNA and protein expression levels of Shh and Ptc were under the detection limit in an uninjured cornea, but Shh but not Ptc was upregulated in a healing, alkali-burned, vascularized cornea.
Regulation (under) of Ptc in cornea associated with cytokine
3) Confidence 0.25 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2684749 Disease Relevance 0.24 Pain Relevance 0.08
On the other hand, Ptc mRNA expression level was unchanged during wound healing in an alkali-burned cornea (data not shown).


Neg (unchanged) Regulation (unchanged) of Ptc in cornea associated with wound healing
4) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.31 Pain Relevance 0
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Regulation (target) of Patched-1 associated with hypoxia and retinal neovascularization
5) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.27 Pain Relevance 0
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Regulation (target) of Ptch1 associated with hypoxia and retinal neovascularization
6) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.27 Pain Relevance 0
The absence of observable adverse effects of HS+MES treatment in normal mice (Fig. 7) in our study suggests its safety, although it is necessary to assess the long-term effects of this treatment.
Regulation (effects) of MES associated with shock
7) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.02 Pain Relevance 0
To determine possible adverse effects of HS+MES treatment in normal mice, we confirmed various parameters on standard diet-fed, lean mice.
Spec (possible) Regulation (effects) of MES associated with shock
8) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.60 Pain Relevance 0.04
Parathyroid hormone-related protein (PTHrP) and Indian Hedgehog (IHH) acting on their respective receptors PTHR1 and PTCH1 exert a tightly coupled signaling relay, which is critical for the regulation of endochondral ossification (Figure 2).
Regulation (acting) of PTCH1 in Parathyroid
9) Confidence 0.18 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.03 Pain Relevance 0
In contrast, Mes5 neurons were barely affected in dt mice.
Regulation (affected) of Mes5 in Mes5
10) Confidence 0.07 Published 2008 Journal Brain Res. Section Abstract Doc Link 18619576 Disease Relevance 0.65 Pain Relevance 0.46

General Comments

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