INT15326

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Context Info
Confidence 0.55
First Reported 1984
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 83
Total Number 85
Disease Relevance 30.96
Pain Relevance 22.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
spinal cord 4
neurons 4
neuronal 3
dorsal root ganglion 3
macrophages 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 116 100.00 Very High Very High Very High
Kinase C 67 100.00 Very High Very High Very High
adenocard 24 100.00 Very High Very High Very High
Pain 89 99.88 Very High Very High Very High
lidocaine 20 99.70 Very High Very High Very High
Spinal cord 173 99.68 Very High Very High Very High
Snapping jaw 20 99.54 Very High Very High Very High
Dorsal horn 32 99.44 Very High Very High Very High
antagonist 78 99.42 Very High Very High Very High
intrathecal 115 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 65 100.00 Very High Very High Very High
Adhesions 28 100.00 Very High Very High Very High
Pain 82 99.60 Very High Very High Very High
Temporomandibular Joint Syndrome 17 99.54 Very High Very High Very High
Leukemia 7 99.16 Very High Very High Very High
Experimental Arthritis 44 99.08 Very High Very High Very High
Nervous System Injury 63 98.64 Very High Very High Very High
Ganglion Cysts 100 98.56 Very High Very High Very High
Diabetes Mellitus 631 98.50 Very High Very High Very High
Diabetic Neuropathy 4 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, NAC treatment for 12 to 24 h led to increased phosphorylation of ERKs, a family of mitogen-activated protein kinase known to involve in cell proliferation, in L6 cells, and specific inhibition of ERKs by PD98059, a selective inhibitor of ERKs, greatly abolished the ability of NAC to increase the number of L6 cells.
Phosphorylation (phosphorylation) of kinase
1) Confidence 0.55 Published 2006 Journal Life Sci. Section Abstract Doc Link 16574161 Disease Relevance 0.09 Pain Relevance 0.07
Forskolin hyperalgesia was antagonized by the Rp isomer of cyclic adenosine-3'5'-monophosphothioate, an analog of cAMP that prevents the phosphorylation of the cAMP protein kinase.
Phosphorylation (phosphorylation) of kinase associated with adenocard and hyperalgesia
2) Confidence 0.42 Published 1991 Journal Neuroscience Section Abstract Doc Link 1722888 Disease Relevance 0.80 Pain Relevance 1.04
[Studies of phosphorylation in rat mast cells (third report)--isolation of calcium-activated, phospholipid, diacylglycerol-dependent protein kinase from rat basophilic leukemia cells (RBL-1 cells)].
Phosphorylation (phospholipid) of kinase in RBL-1 associated with leukemia
3) Confidence 0.28 Published 1985 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 2995215 Disease Relevance 0.10 Pain Relevance 0.11
We have previously shown that lidocaine increases the phosphorylation of focal adhesion kinase (FAK, a nonreceptor tyrosine kinase playing a role in neuronal plasticity and cell death).
Phosphorylation (phosphorylation) of kinase in neuronal associated with lidocaine, death and adhesions
4) Confidence 0.28 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.20 Pain Relevance 0.59
We have previously shown that lidocaine increases the phosphorylation of focal adhesion kinase (FAK, a nonreceptor tyrosine kinase playing a role in neuronal plasticity and cell death).
Phosphorylation (phosphorylation) of kinase in neuronal associated with lidocaine, death and adhesions
5) Confidence 0.28 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.20 Pain Relevance 0.60
It was concluded that the anesthesia-induced decrease in fructose 2,6-bisphosphate levels results at least in part from increased phosphorylation of 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase.
Phosphorylation (phosphorylation) of kinase associated with anesthesia
6) Confidence 0.27 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6089777 Disease Relevance 0 Pain Relevance 0.17
In contrast, AMPH activates phosphoinositide-3 kinase substrates, like protein kinase B/Akt, only in the nuclei of striatal cells but this transient increase induced by AMPH is followed by a delayed decrease in protein kinase B/Akt phosphorylation whether or not the rats have a drug history, suggesting that the phosphoinositide-3 kinase pathway is not essential for AMPH-induced behavioral sensitization.
Neg (not) Spec (whether) Phosphorylation (phosphorylation) of kinase
7) Confidence 0.22 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221378 Disease Relevance 0 Pain Relevance 0.28
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
8) Confidence 0.20 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.06 Pain Relevance 0.50
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Phosphorylation (phosphorylation) of kinase in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
9) Confidence 0.20 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.05 Pain Relevance 0.50
AIMS: To elucidate the neuronal mechanisms underlying chronic pain of the temporomandibular joint (TMJ), expression of phosphorylated extracellular signal-regulated kinase (pERK) in the trigeminal spinal nucleus caudalis (Vc) was studied in rats with a chronically inflamed TMJ.
Phosphorylation (phosphorylated) of kinase in neuronal associated with snapping jaw and lasting pain
10) Confidence 0.20 Published 2007 Journal J Orofac Pain Section Abstract Doc Link 17717961 Disease Relevance 0.54 Pain Relevance 0.51
METHODS: The effects of bupivacaine on the activation of extracellular receptor-activated kinase (phosphorylation to pERK) in rat spinal cord slices, induced by presynaptic release (capsaicin), by presynaptic or postsynaptic ionotropic or metabotropic receptor activation, or by activation of intracellular protein kinase C or protein kinase A and also by a receptor-independent Ca2+ ionophore, were quantitated by immunohistochemistry, counting pERK-positive neurons in the superficial dorsal horn.
Phosphorylation (phosphorylation) of kinase in neurons
11) Confidence 0.20 Published 2006 Journal Anesthesiology Section Body Doc Link 16571978 Disease Relevance 0.09 Pain Relevance 0
Down regulation involved phosphorylation and at least two different kinases, a tyrosine kinase (TK) and MAPK kinase (MEK), mediated DOR down regulation in parallel routes.
Phosphorylation (phosphorylation) of kinase associated with opioid receptor
12) Confidence 0.19 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731019 Disease Relevance 0 Pain Relevance 0.58
Down regulation involved phosphorylation and at least two different kinases, a tyrosine kinase (TK) and MAPK kinase (MEK), mediated DOR down regulation in parallel routes.
Phosphorylation (phosphorylation) of kinase associated with opioid receptor
13) Confidence 0.19 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731019 Disease Relevance 0 Pain Relevance 0.58
Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions.
Phosphorylation (phosphorylation) of kinase associated with adhesions
14) Confidence 0.18 Published 2005 Journal Anesthesiology Section Title Doc Link 16249671 Disease Relevance 0.28 Pain Relevance 0.14
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Phosphorylation (autophosphorylated) of kinase associated with adhesions
15) Confidence 0.18 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
The authors hypothesized that dexmedetomidine increases the expression of active (autophosphorylated) focal adhesion kinase (FAK), a nonreceptor tyrosine kinase playing a pivotal role in cellular plasticity and survival.
Phosphorylation (autophosphorylated) of kinase associated with adhesions
16) Confidence 0.18 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16249671 Disease Relevance 0.27 Pain Relevance 0.14
We found a small number of phosphorylated extracellular signal-regulated kinase (pERK)-labelled neurons in laminae I-II and III-IV of the spinal dorsal horn in the control rats after 0.1 mA stimulation.
Phosphorylation (phosphorylated) of kinase in neurons associated with spinal dorsal horn
17) Confidence 0.17 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009135 Disease Relevance 0.66 Pain Relevance 0.33
In addition to activating D1 dopamine-Gs-coupled-protein kinase A signaling, acute psychostimulant administration activates extracellular-regulated kinase transiently in striatal cells; conversely, inhibition of extracellular-regulated kinase phosphorylation decreases the ability of psychostimulants to elevate locomotor behavior and opioid peptide gene expression.
Phosphorylation (phosphorylation) of kinase associated with dopamine and opioid
18) Confidence 0.17 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221378 Disease Relevance 0 Pain Relevance 0.27
Moreover, a drug challenge in rats with a drug history augments and prolongs striatal extracellular-regulated kinase phosphorylation, possibly contributing to behavioral sensitization.
Phosphorylation (phosphorylation) of kinase
19) Confidence 0.17 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221378 Disease Relevance 0 Pain Relevance 0.28
By Western blot analysis, we identified the underlying molecular mechanism: a suppression of mitogen-activated protein kinase (MAPK) phosphorylation, which is a key event in an endogenous neuroprotective pathway.
Phosphorylation (phosphorylation) of kinase
20) Confidence 0.17 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12904460 Disease Relevance 1.27 Pain Relevance 0.42

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