INT153267

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.06
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccl3) extracellular space (Ccl3) extracellular region (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
saliva 2
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 60 100.00 Very High Very High Very High
ischemia 9 100.00 Very High Very High Very High
Angina 4 100.00 Very High Very High Very High
Inflammation 19 92.80 High High
psoriasis 3 86.08 High High
Arthritis 7 85.48 High High
fibrosis 4 85.04 High High
cytokine 8 70.92 Quite High
antagonist 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 100.00 Very High Very High Very High
Coronary Artery Disease 2 100.00 Very High Very High Very High
Myocardial Infarction 5 95.08 Very High Very High Very High
INFLAMMATION 24 92.80 High High
Acute Coronary Syndrome 3 91.36 High High
Psoriasis 3 86.08 High High
Arthritis 6 85.48 High High
Pulmonary Fibrosis 2 85.04 High High
Disease 11 83.96 Quite High
Reperfusion Injury 3 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of a direct association with cardiac ischemia CCL3 levels were also seen to be elevated in patients with UAP at baseline and significantly down-regulated after 180 days (P<0.001).
Negative_regulation (down-regulated) of CCL3 Binding (association) of associated with angina, coronary artery disease and ischemia
1) Confidence 0.43 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.45 Pain Relevance 0.69
We analyzed the ability of saliva from Rhipicephalus sanguineus (common brown dog tick) to inhibit the binding of the I125-labeled chemokines CCL2, CCL5, and CXCL8, as well as CCL3, to their respective receptors using a scintillation proximity assay.
Spec (analyzed) Negative_regulation (inhibit) of CCL3 Spec (analyzed) Binding (binding) of in saliva associated with chemokine
2) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.61 Pain Relevance 0.45

General Comments

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