INT153268

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 19.00
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
macrophages 3
brain 2
cerebellum 2
lymphocytes 2
lymph nodes 1
Ccr5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 609 100.00 Very High Very High Very High
Sciatic nerve 11 99.68 Very High Very High Very High
Morphine 6 99.44 Very High Very High Very High
cytokine 215 99.04 Very High Very High Very High
opioid receptor 1 98.92 Very High Very High Very High
Inflammation 256 98.84 Very High Very High Very High
antagonist 60 98.28 Very High Very High Very High
Thermal hyperalgesia 6 97.80 Very High Very High Very High
Brush evoked pain 6 96.80 Very High Very High Very High
Multiple sclerosis 121 94.36 High High
Disease Link Frequency Relevance Heat
Infection 463 99.98 Very High Very High Very High
Hypercalcemia 59 99.96 Very High Very High Very High
Targeted Disruption 35 99.60 Very High Very High Very High
Recurrence 32 99.58 Very High Very High Very High
Myocardial Infarction 5 99.50 Very High Very High Very High
Cerebral Malaria 273 99.46 Very High Very High Very High
Chlamydia Infection 342 99.36 Very High Very High Very High
INFLAMMATION 272 98.84 Very High Very High Very High
Hyperalgesia 6 97.80 Very High Very High Very High
Neuropathic Pain 16 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, small molecule inhibitors cause allosteric modifications in CCR5, leading to the induction or stabilization of a conformation of CCR5 that can not be bound by gp120, thereby preventing virus entry.
Positive_regulation (stabilization) of CCR5
1) Confidence 0.66 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0 Pain Relevance 0.17
These data suggest that increases in CCL5, CCR5, and IFN-?
Positive_regulation (increases) of CCR5
2) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.13 Pain Relevance 0.14
Furthermore circulating levels of CCL3 were significantly enhanced after AMI in mice (P=0.02), while CCR5(+) T-cell numbers were increased as well, suggestive of CCL3 driven T-cell homing towards the ischemic area.
Positive_regulation (increased) of CCR5 in T-cell associated with myocardial infarction
3) Confidence 0.61 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.25 Pain Relevance 0.59
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Positive_regulation (up-regulated) of CCR5 in macrophages associated with sciatic nerve
4) Confidence 0.46 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.99 Pain Relevance 1.09
These results corroborate our previous findings that CCR5-dependent mucosal immune responses are required for the efficient clearance of genital chlamydial infection, while functional CCR5 expression reduces infertility as a pathologic consequence of Th1-mediated inflammation associated with infection [22].
Positive_regulation (required) of CCR5 associated with reprotox - general 3, inflammation, chlamydia infection and infection
5) Confidence 0.45 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.80 Pain Relevance 0.17
CCL3 and CCL4 are also CCR5 ligands, but these chemokines were not remarkably elevated compared to CCL5, which was the most abundant CCR5 ligand expressed during the early stages (i.e., < 7 days) of chlamydial infection.
Positive_regulation (abundant) of CCR5 associated with chemokine and chlamydia infection
6) Confidence 0.45 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.60 Pain Relevance 0.15
A mutation in the CCR5 open reading frame results in the premature truncation and a consequent 32-bp deletion in the protein (CCR5 ?
Positive_regulation (results) of CCR5
7) Confidence 0.44 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.16 Pain Relevance 0.04
In later stages, macrophages became CCR1-/CCR5+, while microglia upregulated CCR5.
Positive_regulation (upregulated) of CCR5 in macrophages
8) Confidence 0.43 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.79 Pain Relevance 0.28
A significant increase in CCR5, CCL5, and IFN?
Positive_regulation (increase) of CCR5
9) Confidence 0.42 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.42 Pain Relevance 0.12
The present study revealed that CCR5 and CCL5 mRNAs are elevated in the spleen, iliac lymph nodes (ILNs), and genital mucosa following Chlamydia muriduram challenge.
Positive_regulation (elevated) of CCR5 in lymph nodes associated with chlamydia infection
10) Confidence 0.42 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2543025 Disease Relevance 0.59 Pain Relevance 0.04
Genes encoding induced RANTES, CCR1, CCR3 and CCR5 were selectively confirmed by semi-quantitative RT-PCR.
Positive_regulation (induced) of CCR5
11) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.14 Pain Relevance 0.03
RANTES (p < 0.002), CCR1 (p < 0.036), CCR3 (p < 0.033), and CCR5 (p < 0.026) mRNA were significantly upregulated at peak parasitaemia and remained high thereafter in the experimental mouse model.
Positive_regulation (upregulated) of CCR5
12) Confidence 0.38 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.50 Pain Relevance 0.07
Sarfo and colleagues indicated that RANTES and its receptors CCR3 and CCR5 were upregulated in the cerebellum and cerebrum of post-mortem human CM tissue samples [8].
Positive_regulation (upregulated) of CCR5 in cerebrum associated with cerebral malaria
13) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.60 Pain Relevance 0.20
Belnoue and colleagues showed that the brains of wild -type mice with CM have significantly higher levels of CCR5 than the knockout-type, implicating these molecules in the pathological changes produced in the brain during the infection [9].
Positive_regulation (levels) of CCR5 in brains associated with targeted disruption, infection and cerebral malaria
14) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.93 Pain Relevance 0.28
In conclusion, P. yoelii 17XL infection upregulates RANTES and its corresponding receptors, CCR1, CCR3 and CCR5, in mouse brain, and that ultrastructural changes in the microvascular endothelial layer occurred in the cerebellum of infected mice.
Positive_regulation (upregulates) of CCR5 in brain associated with infection
15) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.50 Pain Relevance 0.14
The upregulation of RANTES, CCR1, CCR3, and CCR5 mRNA, and RANTES protein mediate inflammation and cellular degradation in the cerebellum during P. yoelii 17XL malaria.



Positive_regulation (upregulation) of CCR5 mRNA in cerebellum associated with malaria and inflammation
16) Confidence 0.38 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.44 Pain Relevance 0.08
(CCR-1 and CCR-5), as adjuncts to current standard therapeutic approaches in myeloma-induced hypercalcemia.
Positive_regulation (induced) of CCR-5 associated with hypercalcemia
17) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.80 Pain Relevance 0.09
The increase of CCL3 and CCL5 in the CSF during a relapse correlates with the increase in the expression of their receptor, CCR5 on TH1 lymphocytes, which results in an enhanced migratory activity of these cells towards CCL3 and CCL5.
Positive_regulation (increase) of CCR5 in lymphocytes associated with recurrence
18) Confidence 0.33 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.85 Pain Relevance 0.33
Interestingly, both CCR1 and CCR5 were significantly upregulated in the TA muscle at 6 hours after LPS administration.
Positive_regulation (upregulated) of CCR5 in muscle
19) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.20 Pain Relevance 0.03
Other authors assigned CXCR3 and CCR5 proteins predominantly to Th1 lymphocytes, whereas Th2 lymphocytes produced CCR3 and CCR4 [12,13,18,26].
Positive_regulation (assigned) of CCR5 in lymphocytes
20) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.95 Pain Relevance 0.49

General Comments

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