INT15327

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Context Info
Confidence 0.30
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 4.95
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
liver 4
macrophages 2
brain 2
muscle 1
adipose tissue 1
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 6 99.68 Very High Very High Very High
adenocard 8 99.02 Very High Very High Very High
Hyperalgesia 10 97.96 Very High Very High Very High
antidepressant 1 97.92 Very High Very High Very High
Cannabinoid 30 97.38 Very High Very High Very High
Opioid 3 96.92 Very High Very High Very High
Dopamine 87 96.78 Very High Very High Very High
Neuritis 2 88.84 High High
cocaine 6 85.92 High High
agonist 15 84.76 Quite High
Disease Link Frequency Relevance Heat
Obesity 62 98.78 Very High Very High Very High
Hyperalgesia 10 97.96 Very High Very High Very High
Multiple Sclerosis 7 96.80 Very High Very High Very High
Apoptosis 10 96.20 Very High Very High Very High
Sepsis 189 93.36 High High
Optic Neuritis 2 88.84 High High
Renal Disease 2 86.00 High High
Ganglion Cysts 1 82.84 Quite High
INFLAMMATION 133 79.92 Quite High
Nociception 1 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forskolin hyperalgesia was antagonized by the Rp isomer of cyclic adenosine-3'5'-monophosphothioate, an analog of cAMP that prevents the phosphorylation of the cAMP protein kinase.
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of kinase associated with adenocard and hyperalgesia
1) Confidence 0.30 Published 1991 Journal Neuroscience Section Abstract Doc Link 1722888 Disease Relevance 0.80 Pain Relevance 1.04
In addition to activating D1 dopamine-Gs-coupled-protein kinase A signaling, acute psychostimulant administration activates extracellular-regulated kinase transiently in striatal cells; conversely, inhibition of extracellular-regulated kinase phosphorylation decreases the ability of psychostimulants to elevate locomotor behavior and opioid peptide gene expression.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of kinase associated with dopamine and opioid
2) Confidence 0.12 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221378 Disease Relevance 0 Pain Relevance 0.27
In contrast, AMPH activates phosphoinositide-3 kinase substrates, like protein kinase B/Akt, only in the nuclei of striatal cells but this transient increase induced by AMPH is followed by a delayed decrease in protein kinase B/Akt phosphorylation whether or not the rats have a drug history, suggesting that the phosphoinositide-3 kinase pathway is not essential for AMPH-induced behavioral sensitization.
Negative_regulation (decrease) of Neg (not) Spec (whether) Phosphorylation (phosphorylation) of kinase
3) Confidence 0.11 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221378 Disease Relevance 0 Pain Relevance 0.28
By Western blot analysis, we identified the underlying molecular mechanism: a suppression of mitogen-activated protein kinase (MAPK) phosphorylation, which is a key event in an endogenous neuroprotective pathway.
Negative_regulation (suppression) of Phosphorylation (phosphorylation) of kinase
4) Confidence 0.09 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12904460 Disease Relevance 1.30 Pain Relevance 0.43
Chronic fluoxetine administration inhibits extracellular signal-regulated kinase 1/2 phosphorylation in rat brain.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of kinase in brain associated with fluoxetine
5) Confidence 0.07 Published 2005 Journal J. Neurochem. Section Title Doc Link 15935071 Disease Relevance 0.18 Pain Relevance 0.44
Radicicol inhibited tyrosine phosphorylation of p53/56lyn, a Src family tyrosine kinase and one of the major tyrosine-phosphorylated proteins in LPS-stimulated macrophages.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of kinase in macrophages
6) Confidence 0.05 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7890656 Disease Relevance 0.45 Pain Relevance 0.18
JNK phosphorylation in liver, muscle and adipose tissue were increased in septic animals and atorvastatin induced a downmodulation in the phosphorylation of this serine kinase (Fig. 4A–C).
Negative_regulation (downmodulation) of Phosphorylation (phosphorylation) of kinase in liver associated with obesity
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.69 Pain Relevance 0.04
JNK phosphorylation in liver, muscle and adipose tissue were increased in septic animals and atorvastatin induced a downmodulation in the phosphorylation of this serine kinase (Fig. 4A–C).
Negative_regulation (downmodulation) of in adipose tissue Phosphorylation (phosphorylation) of kinase in liver associated with obesity
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.69 Pain Relevance 0.04
JNK phosphorylation in liver, muscle and adipose tissue were increased in septic animals and atorvastatin induced a downmodulation in the phosphorylation of this serine kinase (Fig. 4A–C).
Negative_regulation (downmodulation) of in muscle Phosphorylation (phosphorylation) of kinase in liver associated with obesity
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.69 Pain Relevance 0.04
CB receptor activation was initially reported to inhibit cAMP formation through its coupling to Gi proteins [43, 91], resulting in a decrease of the protein kinase A-dependent phosphorylation processes as well.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of kinase associated with cannabinoid
10) Confidence 0.00 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644494 Disease Relevance 0.13 Pain Relevance 0.22

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