INT153271

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Context Info
Confidence 0.81
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 11.29
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccl3) extracellular space (Ccl3) extracellular region (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
macrophages 3
SCN 2
monocytes 1
dendritic cells 1
T cells 1
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 20 100.00 Very High Very High Very High
ischemia 4 99.76 Very High Very High Very High
chemokine 479 99.68 Very High Very High Very High
Inflammation 305 99.52 Very High Very High Very High
Central nervous system 300 99.14 Very High Very High Very High
Thermal hyperalgesia 12 99.04 Very High Very High Very High
Brush evoked pain 12 98.04 Very High Very High Very High
Neuropathic pain 20 97.72 Very High Very High Very High
Multiple sclerosis 360 96.80 Very High Very High Very High
cytokine 45 88.60 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 474 99.92 Very High Very High Very High
Cv Unclassified Under Development 2 99.76 Very High Very High Very High
INFLAMMATION 294 99.52 Very High Very High Very High
Central Nervous System Disease 288 99.14 Very High Very High Very High
Hyperalgesia 12 99.04 Very High Very High Very High
Neuropathic Pain 32 98.04 Very High Very High Very High
Demyelinating Disease 468 96.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 95.08 Very High Very High Very High
Myocardial Infarction 5 94.44 High High
Acute Coronary Syndrome 3 90.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCL3 levels are elevated during ACS and released upon ischemia.
Localization (released) of CCL3 associated with ischemia
1) Confidence 0.81 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.27 Pain Relevance 0.53
MIP-1alpha mRNA and its protein were dramatically up-regulated after PSL, and MIP-1alpha was localized on macrophages and Schwann cells in the injured sciatic nerve (SCN).
Localization (localized) of MIP-1alpha in SCN associated with sciatic nerve
2) Confidence 0.78 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.80 Pain Relevance 0.86
MIP-1alpha mRNA and its protein were dramatically up-regulated after PSL, and MIP-1alpha was localized on macrophages and Schwann cells in the injured sciatic nerve (SCN).
Localization (localized) of MIP-1alpha in SCN associated with sciatic nerve
3) Confidence 0.73 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.81 Pain Relevance 0.87
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Localization (localized) of MIP-1alpha in macrophages associated with sciatic nerve
4) Confidence 0.68 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 1.01 Pain Relevance 1.13
The beta-chemokines CCL5/regulated upon activation, normal T cell expressed and secreted, CCL3/macrophage inflammatory protein-1alpha, and CCL4/macrophage inflammatory protein-1beta were increased by 12-h exposure to HIV-1 Tat.
Localization (secreted) of CCL3 in macrophage associated with chemokine, inflammation and acquired immune deficiency syndrome or hiv infection
5) Confidence 0.68 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20403075 Disease Relevance 0.82 Pain Relevance 0.55
These T cells showed an increased migration towards CCL3 and CCL5, suggesting a functional significance of the altered receptor expression [42,52].
Localization (migration) of CCL3 in T cells
6) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.75 Pain Relevance 0.26
Neutralization of the CCR1 ligand CCL3 (MIP-1?)
Localization (Neutralization) of CCL3
7) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.08 Pain Relevance 0.38
In humans, there are 27 CC chemokines, most of which including CCL2, CCL7, CCL11, CCL8, CCL13, CCL1, CCL5, CCL16, CCL14, CCL15, CCL23, CCL18, CCL3 and CCL4, respectively, are encoded as a cluster within chromosome 17q11.
Localization (including) of CCL3 associated with chemokine
8) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.51 Pain Relevance 0.75
Thus, the functional involvement of CCL chemokines during EAE is not only restricted to a well orchestrated recruitment of dendritic cells, monocytes, macrophages, T effector and regulatory cells into the CNS, but also includes a temporal and spatial regulation of TH1 (CCL3, CCL5) or TH2 (CCL2, CCL22) polarization, and monocyte, macrophage and microglial activation (CCL1, CCL2, CCL7, CCL8).
Localization (regulation) of CCL3 in macrophages associated with chemokine, multiple sclerosis and central nervous system
9) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.07 Pain Relevance 0.23
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Localization (localized) of MIP-1alpha in Schwann cells associated with sciatic nerve
10) Confidence 0.23 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 1.01 Pain Relevance 1.13
Thus, the functional involvement of CCL chemokines during EAE is not only restricted to a well orchestrated recruitment of dendritic cells, monocytes, macrophages, T effector and regulatory cells into the CNS, but also includes a temporal and spatial regulation of TH1 (CCL3, CCL5) or TH2 (CCL2, CCL22) polarization, and monocyte, macrophage and microglial activation (CCL1, CCL2, CCL7, CCL8).
Localization (regulation) of CCL3 in dendritic cells associated with chemokine, multiple sclerosis and central nervous system
11) Confidence 0.15 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.07 Pain Relevance 0.23
Thus, the functional involvement of CCL chemokines during EAE is not only restricted to a well orchestrated recruitment of dendritic cells, monocytes, macrophages, T effector and regulatory cells into the CNS, but also includes a temporal and spatial regulation of TH1 (CCL3, CCL5) or TH2 (CCL2, CCL22) polarization, and monocyte, macrophage and microglial activation (CCL1, CCL2, CCL7, CCL8).
Localization (regulation) of CCL3 in monocytes associated with chemokine, multiple sclerosis and central nervous system
12) Confidence 0.15 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.07 Pain Relevance 0.23

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