INT153277

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.76
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar6) plasma membrane (Lpar6) molecular_function (Lpar6)
biological_process (Lpar6) signal transducer activity (Lpar6)
Anatomy Link Frequency
endothelial cells 1
hair 1
Lpar6 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 20 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
agonist 30 86.48 High High
antagonist 30 5.00 Very Low Very Low Very Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 22 100.00 Very High Very High Very High
Injury 13 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
Alopecia 10 100.00 Very High Very High Very High
Pulmonary Fibrosis 7 100.00 Very High Very High Very High
Internal Fibrosis 1 100.00 Very High Very High Very High
Targeted Disruption 30 99.76 Very High Very High Very High
Disease 15 99.18 Very High Very High Very High
Cancer 49 72.64 Quite High
Obesity 1 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies on gene targeting mice and family diseases of these receptors revealed that LPA is involved in both pathological and physiological states including brain development (LPA1), neuropathy pain (LPA1), lung fibrosis (LPA1), renal fibrosis (LPA1) protection against radiation-induced intestinal injury (LPA2), implantation (LPA3) and hair growth (P2Y5).
Gene_expression (involved) of P2Y5 in hair associated with pain, neuropathic pain, pulmonary fibrosis, disease, fibrosis, injury, internal fibrosis and alopecia
1) Confidence 0.49 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18621144 Disease Relevance 1.45 Pain Relevance 0.57
In chronological order based on the first publication, these include the GPR87 (Tabata et al., 2007; Wetter et al., 2009), P2Y5 (Pasternack et al., 2008; Shimomura et al., 2008), P2Y10 (Murakami et al., 2008) and GPR35 (Oka et al., 2010) gene products.
Gene_expression (products) of P2Y5
2) Confidence 0.30 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
Interestingly, human umbilical vein endothelial cells (HUVEC) express LPA1 and P2Y5; and knock-down of the latter partially inhibited LPA-induced contraction, suggesting a role for this receptor in the barrier properties of vascular endothelia (Yanagida et al., 2009).
Gene_expression (express) of P2Y5 in endothelial cells associated with targeted disruption
3) Confidence 0.26 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

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