INT153288

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1, Lpar6) plasma membrane (Lpar1, Lpar6) signal transducer activity (Lpar1, Lpar6)
molecular_function (Lpar6) biological_process (Lpar6) cytoplasm (Lpar1)
Lpar1 (Mus musculus)
Lpar6 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 9 74.08 Quite High
fibrosis 11 72.64 Quite High
antagonist 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 8 86.16 High High
Neuropathic Pain 12 74.96 Quite High
Pain 9 74.08 Quite High
Pulmonary Fibrosis 4 73.04 Quite High
Internal Fibrosis 1 71.28 Quite High
Injury 7 65.68 Quite High
Alopecia 7 62.56 Quite High
Cancer 25 33.84 Quite Low
Obesity 1 28.96 Quite Low
Diabetes Mellitus 3 28.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So far, five GPCRs, designated LPA1-5, and, more recently, two additional GPCRs, GPR87 and P2Y5, have been identified as receptors for LPA.
LPA Binding (receptors) of P2Y5
1) Confidence 0.31 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18621144 Disease Relevance 0.78 Pain Relevance 0.36
Now that GPR87 has been shown independently to be activated by LPA (Wetter et al., 2009), it might qualify for the designation LPA6; consequently, P2Y5 would be LPA7, P2Y10 and GPR35, if confirmed, would be LPA8 and LPA9, respectively.
LPA Binding (activated) of LPA6
2) Confidence 0.11 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0

General Comments

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