INT153289

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1, Gpr87) plasma membrane (Lpar1, Gpr87) signal transducer activity (Lpar1, Gpr87)
cytoplasm (Lpar1)
Anatomy Link Frequency
ovary 1
Lpar1 (Mus musculus)
Gpr87 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 16 79.40 Quite High
antagonist 30 76.20 Quite High
Pain 13 74.96 Quite High
fibrosis 20 72.64 Quite High
dorsal root ganglion 8 62.80 Quite High
allodynia 4 53.24 Quite High
chung model 2 48.64 Quite Low
Action potential 4 42.16 Quite Low
Dorsal horn 2 32.04 Quite Low
tail-flick 2 26.72 Quite Low
Disease Link Frequency Relevance Heat
Disease 15 86.16 High High
Neuropathic Pain 22 79.40 Quite High
Pain 13 74.96 Quite High
Pulmonary Fibrosis 7 73.04 Quite High
Nociception 4 71.32 Quite High
Internal Fibrosis 1 71.28 Quite High
Injury 13 65.68 Quite High
Ganglion Cysts 10 62.80 Quite High
Alopecia 10 62.56 Quite High
Targeted Disruption 30 46.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So far, five GPCRs, designated LPA1-5, and, more recently, two additional GPCRs, GPR87 and P2Y5, have been identified as receptors for LPA.
LPA Binding (receptors) of GPR87
1) Confidence 0.29 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18621144 Disease Relevance 0.78 Pain Relevance 0.36
Now that GPR87 has been shown independently to be activated by LPA (Wetter et al., 2009), it might qualify for the designation LPA6; consequently, P2Y5 would be LPA7, P2Y10 and GPR35, if confirmed, would be LPA8 and LPA9, respectively.
LPA Binding (activated) of GPR87
2) Confidence 0.08 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
The data supporting LPA as a ligand for GPR87 come from heterologous expression studies conducted in stably transfected Chinese hamster ovary (CHO) cells with a GPR87-G16 fusion protein (Tabata et al., 2007) and from using the Tango¬ô?
LPA Binding (ligand) of GPR87 in ovary
3) Confidence 0.08 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.40 Pain Relevance 0.31

General Comments

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