INT153292

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C5AR1) plasma membrane (C5AR1) signal transducer activity (C5AR1)
Anatomy Link Frequency
microglial cells 1
C5AR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 100.00 Very High Very High Very High
Neuropathic pain 7 99.52 Very High Very High Very High
Pain 1 98.44 Very High Very High Very High
Central nervous system 1 90.56 High High
Opioid 1 90.00 High High
Morphine 4 84.40 Quite High
glial activation 2 81.12 Quite High
analgesia 2 44.48 Quite Low
Inflammation 3 30.32 Quite Low
neuralgia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Neuropathic Pain 8 99.52 Very High Very High Very High
Pain 1 98.44 Very High Very High Very High
Nociception 1 94.44 High High
INFLAMMATION 3 30.32 Quite Low
Hyperalgesia 1 25.00 Low Low
Bacterial Respiratory Disease 1 5.00 Very Low Very Low Very Low
Fungal Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is increasing evidence that uncontrolled activation of microglial cells under neuropathic pain conditions induces the release of proinflammatory cytokines (interleukin - IL-1beta, IL-6, tumor necrosis factor - TNF-alpha), complement components (C1q, C3, C4, C5, C5a) and other substances that facilitate pain transmission.
Localization (release) of C5a in microglial cells associated with pain, necrosis, cancer, neuropathic pain and cytokine
1) Confidence 0.68 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 18622054 Disease Relevance 0.79 Pain Relevance 0.91
The disappearance of 9-H in the 1H NMR spectra and the appearance of C-5a in the 13C NMR spectra as an azomethine carbon signal at ?
Localization (appearance) of C-5a
2) Confidence 0.68 Published 2007 Journal Beilstein J Org Chem Section Body Doc Link PMC1847824 Disease Relevance 0 Pain Relevance 0

General Comments

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