INT153296

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.72
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
colon 2
nucleus 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 4 87.72 High High
dexamethasone 4 78.28 Quite High
spastic colon 1 75.00 Quite High
Action potential 1 61.72 Quite High
tetrodotoxin 1 60.32 Quite High
sodium channel 1 48.68 Quite Low
agonist 1 36.72 Quite Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 91.16 High High
Stress 5 90.68 High High
Functional Bowel Disorder 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein expression of CRFR1 and CRFR2 in the proximal colon was similar under baseline conditions and not affected by exposure to an OF stressor in either cohort.
Neg (not) Regulation (affected) of Gene_expression (expression) of CRFR1 in colon
1) Confidence 0.39 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07
Direct inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures.
Regulation (effect) of Gene_expression (expression) of corticotrophin-releasing hormone in nucleus
2) Confidence 0.23 Published 2008 Journal J. Neuroendocrinol. Section Title Doc Link 18624927 Disease Relevance 0.09 Pain Relevance 0.27

General Comments

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