INT153297

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 11.09
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV) cytoskeleton (MEFV) nucleus (MEFV)
intracellular (MEFV) cytoplasm (MEFV)
Anatomy Link Frequency
arm 2
leukocyte 1
knees 1
MEFV (Homo sapiens)
MEFV - E148Q (1)
Pain Link Frequency Relevance Heat
Inflammation 172 100.00 Very High Very High Very High
Fibrositis 97 100.00 Very High Very High Very High
abdominal pain 13 97.92 Very High Very High Very High
corticosteroid 2 96.68 Very High Very High Very High
Inflammatory response 7 80.16 Quite High
cva 3 52.24 Quite High
Arthritis 9 20.20 Low Low
Pain 23 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 343 100.00 Very High Very High Very High
Familial Mediterranean Fever 219 100.00 Very High Very High Very High
INFLAMMATION 184 100.00 Very High Very High Very High
Fibromyalgia 97 100.00 Very High Very High Very High
Proteinuria 6 99.04 Very High Very High Very High
Abdominal Pain 13 97.92 Very High Very High Very High
Spirochete Infection 10 97.16 Very High Very High Very High
Systemic Lupus Erythematosus 6 96.16 Very High Very High Very High
Purpura 6 94.88 High High
Vasculitis 10 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
He was later found to carry E148Q polymorphism of MEFV, the gene responsible for familial Mediterranean fever.
Regulation (responsible) of MEFV (E148Q) associated with fever
1) Confidence 0.40 Published 2008 Journal Lupus Section Abstract Doc Link 18625654 Disease Relevance 0.54 Pain Relevance 0.10
In 1992, the gene responsible for Familial Mediterranean Fever (FMF), MEFV, was found to reside on the short arm of chromosome 16 [7].
Regulation (responsible) of FMF in arm associated with familial mediterranean fever and fever
2) Confidence 0.39 Published 2003 Journal BMC Nephrol Section Body Doc Link PMC194618 Disease Relevance 2.40 Pain Relevance 0.11
In 1992, the gene responsible for Familial Mediterranean Fever (FMF), MEFV, was found to reside on the short arm of chromosome 16 [7].
Regulation (responsible) of MEFV in arm associated with familial mediterranean fever and fever
3) Confidence 0.39 Published 2003 Journal BMC Nephrol Section Body Doc Link PMC194618 Disease Relevance 2.40 Pain Relevance 0.11
Analysis of a larger cohort and functional studies of the R2022Q variant pyrin protein may assist in understanding the role of this variant in both FMS and FMF.


Regulation (role) of FMF associated with familial mediterranean fever and fibrositis
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.96 Pain Relevance 0.16
For example, there are regions, such as the Aegean region, represented by Izmir, and territories where the majority of patients with FMF do not exhibit any MEFV mutations.
Neg (not) Regulation (exhibit) of MEFV associated with familial mediterranean fever and fever
5) Confidence 0.38 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2825617 Disease Relevance 1.20 Pain Relevance 0
Thus our results do not completely rule out the possibility that the E148Q mutation has an upregulating effect on inflammation in both FMF and other chronic inflammatory processes.
Regulation (effect) of FMF associated with inflammation and familial mediterranean fever
6) Confidence 0.38 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2825617 Disease Relevance 1.04 Pain Relevance 0.10
Pyrin presumably participates in a complex interplay with the PYD protein superfamily, lipopolysaccharide (LPS) via Toll-like receptor family and procaspase-1 activation, and is implicated in the homeostatic control of inflammation through leukocyte apoptosis, IL-1?
Regulation (participates) of Pyrin in leukocyte associated with inflammation and apoptosis
7) Confidence 0.26 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2825617 Disease Relevance 1.07 Pain Relevance 0.05
In 1773, Denman had commented on a “peculiarity” in puerperal fever which he believed had never been noticed before—namely “an erysipelatous appearance of a dusky red colour on the knuckles, wrists, elbows, knees, or ankles, about the size of a shilling and sometimes larger”.89 Fifteen years later, in his account of the epidemic lasting from 1787 to 1788, John Clarke also mentioned the relevance of “erysipelas” to this disease.90 Philip Pitt Walsh, whilst arguing that puerperal fever was a manifestation of the category “synochus”, also stated that the inflammation involved was of an erysipelatous kind.91

The Influence of Morbid Anatomy on Theories of Puerperal Fever

Regulation (peculiarity) of puerperal fever in knees associated with skin infection, inflammation, disease and fever
8) Confidence 0.06 Published 2005 Journal Medical History Section Body Doc Link PMC1088248 Disease Relevance 1.47 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox