INT1533

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1975
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 105
Total Number 107
Disease Relevance 46.54
Pain Relevance 16.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
blood 12
plasma 6
amniotic fluid 2
renal blood vessels 1
liver 1
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 243 100.00 Very High Very High Very High
bradykinin 98 100.00 Very High Very High Very High
Enkephalin 73 100.00 Very High Very High Very High
agonist 17 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
sSRI 1 100.00 Very High Very High Very High
antagonist 91 99.96 Very High Very High Very High
Clonidine 17 99.82 Very High Very High Very High
Catecholamine 21 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 62 100.00 Very High Very High Very High
Diabetes Mellitus 1071 99.96 Very High Very High Very High
Heart Disease 28 99.96 Very High Very High Very High
Anaemia 5 99.92 Very High Very High Very High
Cv Unclassified Under Development 68 99.88 Very High Very High Very High
Stress 74 99.86 Very High Very High Very High
Coronary Artery Disease 147 99.76 Very High Very High Very High
Coronary Heart Disease 36 99.72 Very High Very High Very High
Arteriosclerosis Obliterans 2 99.66 Very High Very High Very High
Breast Cancer 3 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Fifty-four women were randomized to receive either angiotensin II or ephedrine infusion intravenously during spinal anesthesia for elective cesarean section delivery.
Negative_regulation (receive) of angiotensin II in spinal
1) Confidence 0.42 Published 1998 Journal Anesthesiology Section Body Doc Link 9637639 Disease Relevance 0 Pain Relevance 0
We compare the effects of two of the main angiotensin convertase enzyme inhibitors, captopril and enalapril, aiming to evaluate their effects in the arterial circulation performance, micro-circulation, and changes in regional blood flow, assuming their property of lowering the angiotensin II blood levels, a very strong peripheral vasoconstrictor.
Negative_regulation (inhibitors) of angiotensin in blood
2) Confidence 0.42 Published 1990 Journal Arch Inst Cardiol Mex Section Abstract Doc Link 2198852 Disease Relevance 0.15 Pain Relevance 0
Whether chronic angiotensin-II blockade is beneficial is unknown.
Spec (Whether) Negative_regulation (blockade) of angiotensin-II
3) Confidence 0.42 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1198258 Disease Relevance 0.60 Pain Relevance 0.05
However, there are few studies focusing on angiotensin blockade in the management of the obese hypertensive patient.
Negative_regulation (blockade) of angiotensin associated with hypertension and obesity
4) Confidence 0.42 Published 2007 Journal Cardiovasc Diabetol Section Body Doc Link PMC2077861 Disease Relevance 1.62 Pain Relevance 0
Medication use was modeled using indicator variables for ACE inhibitors, angiotensin-receptor blockers (ARBs), diuretics, beta-blockers, lipid-lowering medications, aspirin, nonsteroidal antiinflammatory drugs (NSAIDs), and cyclooxygenase (COX) inhibitors.
Negative_regulation (inhibitors) of angiotensin associated with aspirin, inflammation, beta blocker and cinod
5) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920916 Disease Relevance 0.56 Pain Relevance 0.24
Despite the normal level of AGT activity in ZSD patients, hyperoxaluria has been reported in several ZSD patients.
Negative_regulation (level) of AGT associated with hyperoxaluria
6) Confidence 0.42 Published 2006 Journal Mol. Genet. Metab. Section Abstract Doc Link 16621644 Disease Relevance 0.78 Pain Relevance 0
In some clinical settings, inactivation of the renin-angiotensin system may contribute to their antihypertensive effect.
Negative_regulation (inactivation) of angiotensin
7) Confidence 0.42 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6084128 Disease Relevance 0 Pain Relevance 0.09
Inhibition of the rennin–angiotensin–aldosterone system may be achieved by administration of ACE inhibitors.
Negative_regulation (Inhibition) of angiotensin
8) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2903466 Disease Relevance 0.68 Pain Relevance 0
A presynaptically supramaximal concentration of the alpha-adrenergic agonist oxymetazoline prevented the facilitatory action of yohimbine, but not that of angiotensin II.
Negative_regulation (prevented) of angiotensin II associated with agonist
9) Confidence 0.42 Published 1977 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 840318 Disease Relevance 0 Pain Relevance 0.39
In people with diabetes, inhibitors of the renin-angiotensin system (RAS) may have unique advantages for initial or early therapy of hypertension.
Negative_regulation (inhibitors) of angiotensin associated with diabetes mellitus and hypertension
10) Confidence 0.41 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.23 Pain Relevance 0.18
Importantly, along with the incomplete blockade of RAAS, both ACE inhibitors and ARBs lead to a substantial compensatory raise in the circulating active renin and angiotensin peptides that may eventually limit their therapeutic potential (Stanton 2003).
Negative_regulation (raise) of angiotensin
11) Confidence 0.41 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.28 Pain Relevance 0.17
As in cardiac disease, blockade of the renin-angiotensin system may offer another therapeutic target.
Negative_regulation (blockade) of angiotensin associated with heart disease
12) Confidence 0.41 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1166544 Disease Relevance 0.90 Pain Relevance 0.04
Treatment with angiotensin-converting enzyme inhibitors].
Negative_regulation (inhibitors) of angiotensin
13) Confidence 0.41 Published 1990 Journal Arch Inst Cardiol Mex Section Title Doc Link 2198852 Disease Relevance 0.25 Pain Relevance 0.07
For example, the early intervention of diagnosing and aggressively treating blood pressure in these patients, particularly blockade of the renin-angiotensin system, has the potential of preventing LVH, cardiovascular complications, and mortality [79].
Negative_regulation (blockade) of angiotensin in blood associated with left ventricular hypertrophy
14) Confidence 0.41 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.95 Pain Relevance 0
The major effect of ACE inhibition in cardiac disorders may therefore not be due to inhibition of systemic angiotensin production, but due to reduced tissue angiotensin II activity.


Negative_regulation (reduced) of angiotensin II
15) Confidence 0.41 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 0.44 Pain Relevance 0.14
[Angiotensin I converting inhibitors in connection with anesthesia and surgery].
Negative_regulation (inhibitors) of Angiotensin associated with anesthesia
16) Confidence 0.40 Published 1992 Journal Ugeskr. Laeg. Section Title Doc Link 1311881 Disease Relevance 0.24 Pain Relevance 0.10
The patients with coronary artery disease also had a reduction in cardiac index during angiotensin (average, 0.44 L. per minute per square meter) and the heart rate was unchanged in four subjects, increased in two subjects, and decreased in two subjects.
Negative_regulation (reduction) of angiotensin in heart associated with coronary artery disease
17) Confidence 0.39 Published 1975 Journal Am. Heart J. Section Abstract Doc Link 1119366 Disease Relevance 0.65 Pain Relevance 0.08
The acute effects of E observed in normotensive patients with effort-induced angina pectoris seems to be related to the inhibition of angiotensin at the coronary level and to its antiadrenergic action.
Negative_regulation (inhibition) of angiotensin associated with angina
18) Confidence 0.39 Published 1988 Journal Clin Cardiol Section Abstract Doc Link 2835195 Disease Relevance 0.65 Pain Relevance 0.45
Cerebral autoregulation was evaluated by two formal tests; blood pressure increase by infusion of angiotensin and blood pressure decrease by caval block.
Negative_regulation (decrease) of angiotensin in blood
19) Confidence 0.38 Published 1990 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815330 Disease Relevance 0.54 Pain Relevance 0.31
As the roles of the RAAS in the pathophysiology of several diseases was explored, so did the realization of the importance of inhibiting the actions of angiotensin II.
Negative_regulation (inhibiting) of angiotensin II associated with disease
20) Confidence 0.37 Published 1998 Journal Indian J. Exp. Biol. Section Abstract Doc Link 10093499 Disease Relevance 0.93 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox