INT153300

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 39.97
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 8
leucocytes 4
erythrocyte 2
platelet 2
blood 2
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 216 100.00 Very High Very High Very High
Inflammatory response 31 100.00 Very High Very High Very High
abatacept 120 99.98 Very High Very High Very High
beta blocker 3 99.98 Very High Very High Very High
Arthritis 29 99.00 Very High Very High Very High
sSRI 5 98.78 Very High Very High Very High
Inflammatory marker 84 98.68 Very High Very High Very High
diclofenac 53 97.16 Very High Very High Very High
Etanercept 27 96.60 Very High Very High Very High
Restless leg syndrome 2 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 776 100.00 Very High Very High Very High
Colon Cancer 74 99.84 Very High Very High Very High
Depressive Disorder 2 99.70 Very High Very High Very High
Cardiovascular Disease 271 99.52 Very High Very High Very High
Diabetes Mellitus 611 99.28 Very High Very High Very High
Depression 14 99.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 90 99.16 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 126 99.14 Very High Very High Very High
Arthritis 30 99.00 Very High Very High Very High
Body Weight 51 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRP expression rapidly decreased in parallel with epithelial damage in the allografts: 16% (P < .0001) of preserved cells had a CRP staining intensity of 0.9 ± 0.5 (P < .01) and a CRP index of 46 ± 31 (P < .001) on day 7.
Negative_regulation (decreased) of Gene_expression (expression) of CRP
1) Confidence 0.58 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.14 Pain Relevance 0
CRP expression was observed in all implants in the bronchial wall during initial ischemic damage, and then decreased in the autografts.
Negative_regulation (decreased) of Gene_expression (expression) of CRP
2) Confidence 0.58 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.06 Pain Relevance 0
Treatment with a statin for several weeks has been shown to decrease CRP production [12] and to reduce the expression of IL-6, IL-8, and MCP-1 mRNA in peripheral blood cells and to decrease serum cytokine concentrations [31,32].
Negative_regulation (decrease) of Gene_expression (production) of CRP in blood cells associated with cytokine
3) Confidence 0.55 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.45 Pain Relevance 0.24
INVESTIGATIONS: Physical examination, CBC, blood chemistry panel, measurement of erythrocyte sedimentation rate and C-reactive protein level, liver function profile, urinalysis, lumbar puncture, blood cultures, urine cultures, cerebrospinal fluid culture, stool analysis and cultures, multiple viral studies including hepatitis serologies, measurement of antineutrophil cytoplasmic autoantibody levels, urine protein electrophoresis, serum protein electrophoresis, CT of the head, chest, abdomen and pelvis, MRI of the brain, temporal artery biopsy and pathologic analysis, scrotal ultrasonography, right spermatic cord biopsy and pathologic analysis.
Negative_regulation (measurement) of Gene_expression (level) of C-reactive protein in blood
4) Confidence 0.43 Published 2008 Journal Nature clinical practice. Urology Section Body Doc Link 18626512 Disease Relevance 0.19 Pain Relevance 0
For comparison, H1 and H5, which included the triallelic proxy, were both associated with higher CRP levels.
Negative_regulation (higher) of Gene_expression (levels) of CRP
5) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.32 Pain Relevance 0
Selective serotonin reuptake inhibitor (SSRI) therapy in subjects with depressive disorder significantly decreased CRP levels whether or not the depressive condition was resolved [19].
Neg (not) Spec (whether) Negative_regulation (decreased) of Spec (whether) Gene_expression (levels) of CRP associated with depression, ssri and depressive disorder
6) Confidence 0.42 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.24 Pain Relevance 0.43
Similarly antihypertensive medications such as beta blockers decreased overall CRP levels.
Negative_regulation (decreased) of Gene_expression (levels) of CRP associated with beta blocker
7) Confidence 0.42 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.32 Pain Relevance 0.41
Other predictors of premature treatment termination in this study included low c-reactive protein level, older age, greater disability, and higher previous number of DMARDs.33
Negative_regulation (included) of Gene_expression (level) of c-reactive protein
8) Confidence 0.41 Published 2009 Journal Patient preference and adherence Section Body Doc Link PMC2792871 Disease Relevance 0.22 Pain Relevance 0.45
Of note, 3 children had a mean starting CRP value of 21.8 ± 9.2 mg/L ("high CRP group"), which declined to 0.2 mg/L in each child (p = 0.052) after hyperbaric therapy.
Negative_regulation (declined) of Gene_expression (value) of CRP
9) Confidence 0.41 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC2244616 Disease Relevance 0.18 Pain Relevance 0.04
As illustrated in figure 2, four subjects in the placebo group exhibited elevated CRP levels (>5 ?
Negative_regulation (exhibited) of Gene_expression (levels) of CRP
10) Confidence 0.41 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.38 Pain Relevance 0.42
with CRP and IL-6 were strongest and most consistent for the 8 individuals
Negative_regulation (were) of Gene_expression (consistent) of CRP
11) Confidence 0.41 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 1.22 Pain Relevance 0.28
increases in repeated measures of CRP, IL-6, and WBCs with increases in
Negative_regulation (repeated) of Gene_expression (measures) of CRP
12) Confidence 0.41 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 1.78 Pain Relevance 0.24
CRP-stimulated production of IL-6, but not MCP-1, was modestly attenuated by short-term treatment with pravastatin.



Negative_regulation (attenuated) of Gene_expression (production) of CRP-stimulated
13) Confidence 0.40 Published 2008 Journal Archives of Drug Information Section Abstract Doc Link PMC2817441 Disease Relevance 0 Pain Relevance 0.10
Some studies of elderly subjects showed either the highest levels of CRP in APOE ?
Negative_regulation (showed) of Gene_expression (levels) of CRP
14) Confidence 0.40 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.32 Pain Relevance 0
Pravastatin reduced CRP-stimulated IL-6 production from 36.6 ± 4.3 ng/mL (median 34.1) to 27.4 ± 3.3 ng/mL (median 25.5), an average of –19.7% ± 8.3% after 6 hours of incubation (P = 0.02, Figure 2) but not after longer periods of incubation (Table 1).
Negative_regulation (reduced) of Gene_expression (production) of CRP-stimulated
15) Confidence 0.40 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0 Pain Relevance 0.10
A nested case-control study showed that individuals with CRP concentrations in the highest quartile had a significantly higher risk for the incidence of colon cancer compared with individuals in the lowest quartile.13 In contrast, another prospective study demonstrated that an elevated plasma CRP level was not a predictor of colorectal cancer but was merely increased after the onset of colorectal cancer.14
Negative_regulation (predictor) of Gene_expression (level) of CRP in plasma associated with colon cancer
16) Confidence 0.40 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687750 Disease Relevance 1.91 Pain Relevance 0.45
A significant correlation was observed between IL-6 and CRP levels (r = 0.4; p < 0.01) in all groups.
Negative_regulation (observed) of Gene_expression (levels) of CRP
17) Confidence 0.39 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993951 Disease Relevance 0.41 Pain Relevance 0.15
Sahlin and colleagues [25] and Harris and his coworkers [30] have found these conditions to substantially suppress the resynthesis of CrP.
Negative_regulation (suppress) of Gene_expression (resynthesis) of CrP
18) Confidence 0.38 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0 Pain Relevance 0
About 50% of adults 40+ have CRP levels indicating CVD risk (CRP?
Negative_regulation (have) of Gene_expression (levels) of CRP associated with cardiovascular disease
19) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722089 Disease Relevance 1.17 Pain Relevance 0.14
Interestingly, when we compared the hsCRP levels in CAD-affected subjects who were followed up for 4 years over telephone to assess their cardiovascular health, we found that about 70% of those who developed a recurrent event were in the top hsCRP quartile (>3.58?
Negative_regulation (were) of Gene_expression (quartile) of hsCRP associated with coronary artery disease
20) Confidence 0.36 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC2989863 Disease Relevance 0.82 Pain Relevance 0.15

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