INT15332

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Context Info
Confidence 0.04
First Reported 1991
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Irs2) cytosol (Irs2) plasma membrane (Irs2)
cellular_component (Irs2)
Anatomy Link Frequency
chromaffin cells 1
Irs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 1 98.46 Very High Very High Very High
Calcium channel 1 97.96 Very High Very High Very High
tetrodotoxin 1 97.92 Very High Very High Very High
sodium channel 1 97.06 Very High Very High Very High
Nav1.7 1 96.76 Very High Very High Very High
ischemia 1 85.32 High High
Inflammation 1 82.72 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 85.32 High High
Neurodegenerative Disease 1 84.92 Quite High
INFLAMMATION 1 82.72 Quite High
Diabetes Mellitus 1 82.16 Quite High
Disease 2 77.00 Quite High
Attention Deficit Hyperactivity Disorder 1 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The K+ channel blocker tetraethylammonium did not modify K(+)-evoked release of Ps4 and Ps5.
Neg (not) Regulation (modify) of Ps4
1) Confidence 0.04 Published 1991 Journal Neuroscience Section Abstract Doc Link 1722891 Disease Relevance 0 Pain Relevance 0.10
In adrenal chromaffin cells, GSK-3 inhibition caused up-regulation of voltage-dependent Nav1.7 sodium channel, enhancing voltage-dependent calcium channel gating and catecholamine exocytosis; conversely, chronic treatment with GSK-3 inhibitors caused down-regulation of insulin receptor, IRS-1, IRS-2, and Akt1 levels.
Regulation (regulation) of IRS-2 in chromaffin cells associated with catecholamine, calcium channel, sodium channel and nav1.7
2) Confidence 0.03 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19273146 Disease Relevance 0.56 Pain Relevance 0.33

General Comments

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