INT153321

Context Info Confidence 0.49 First Reported 2008 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.31 Pain Relevance 0.53

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4) cytoplasm (Dlg4)

Anatomy Link Frequency brain 2 Dlg4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 3 98.84 addiction 7 98.48 Spinal cord 42 68.52 imagery 20 64.44 intrathecal 22 8.96 Eae 58 5.00 antagonist 56 5.00 Inflammation 52 5.00 Dorsal horn 42 5.00 withdrawal 38 5.00

Disease Link Frequency Relevance Heat Morphine Dependence 2 98.84 Decapitation 2 58.28 Inflammatory Pain 56 5.00 INFLAMMATION 52 5.00 Hypersensitivity 32 5.00 Nociception 20 5.00 Pain 14 5.00 Neuropathic Pain 4 5.00 Increased Venous Pressure Under Development 3 5.00 Hyperalgesia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, PSD-95:GFP overexpression was previously shown to affect synaptic properties and even occlude forms of activity-induced synaptic plasticity [67]–[71].

Positive_regulation (overexpression) of Gene_expression (overexpression) of PSD-95

1) Confidence 0.49 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.03

OBJECTIVE: To observe the expression of brain-derived neurotrophic factor (BDNF) and postsynaptic density-95 (PSD-95) in hippocampal CA1 region of rat with morphine dependence for different times and withdrawn for 1 week, and investigate the influence of that morphine dependence is withdrawn on rat hippocampal CA1 area.

Spec (observe) Positive_regulation (observe) of Gene_expression (expression) of PSD-95 in brain associated with addiction and morphine

2) Confidence 0.46 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 18630696 Disease Relevance 0.19 Pain Relevance 0.36

N-cadherin and PSD-95 were used as loading controls and markers for crude membrane fraction, whereas ?

Positive_regulation (whereas) of Gene_expression (used) of PSD-95

3) Confidence 0.20 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.06 Pain Relevance 0.07

N-cadherin and PSD-95 were used as loading controls and markers for crude membrane fraction, whereas ?

Positive_regulation (markers) of Gene_expression (used) of PSD-95

4) Confidence 0.20 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.06 Pain Relevance 0.07

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