INT153371

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 7.33
Pain Relevance 7.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
Anatomy Link Frequency
neurons 2
OFC 2
insular cortex 1
shell 1
amygdala 1
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 690 100.00 Very High Very High Very High
Hippocampus 315 99.92 Very High Very High Very High
Dopamine 52 99.08 Very High Very High Very High
cocaine 30 98.80 Very High Very High Very High
amygdala 250 98.52 Very High Very High Very High
imagery 8 98.20 Very High Very High Very High
Limbic system 8 96.32 Very High Very High Very High
Serotonin 34 93.84 High High
noradrenaline 11 93.24 High High
Pain 12 92.76 High High
Disease Link Frequency Relevance Heat
Poisoning 6 100.00 Very High Very High Very High
Urological Neuroanatomy 74 99.88 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 14 99.54 Very High Very High Very High
Emergencies 1 99.30 Very High Very High Very High
Stress 171 98.64 Very High Very High Very High
Post-traumatic Stress Disorder 32 98.12 Very High Very High Very High
Anxiety Disorder 298 97.36 Very High Very High Very High
Schizophrenia 97 97.28 Very High Very High Very High
Injury 11 96.56 Very High Very High Very High
Cognitive Disorder 58 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local and state health departments can train emergency and urgent care physicians in the recognition of CFP and make them aware that symptoms can persist for months to years.
CFP Binding (recognition) of associated with emergencies and poisoning
1) Confidence 0.47 Published 2009 Journal MMWR Morb. Mortal. Wkly. Rep. Section Abstract Doc Link 19325530 Disease Relevance 1.21 Pain Relevance 0.20
Thus, a three-way interaction among the PFC, VH and NA may be critical for switching behaviors.
PFC Binding (interaction) of associated with nucleus accumbens and hippocampus
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.66
Six rats had microelectrodes implanted in the PFC, NA and VH (Figure S2).
PFC Binding (implanted) of associated with nucleus accumbens and hippocampus
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0.08 Pain Relevance 0.36
The precise component of the instrumental task associated with the PFC-NA correlation cannot be discerned from our data.
PFC-NA Binding (associated) of associated with nucleus accumbens
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.34
During spatial exploration, a strong correlation existed between the PFC, NA (both core and shell), and the VH for simultaneous peaks in the theta range.
PFC Binding (existed) of in shell associated with nucleus accumbens and hippocampus
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.59
Here we showed that NA up states can become transiently synchronized with PFC activity, indicating NA neurons could also be gated by PFC inputs.
PFC Binding (gated) of in neurons associated with nucleus accumbens
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.39
However, the behavioral conditions in which such synchrony was not evident included similar spatial information and locomotor levels, suggesting that these elements are not associated with the PFC-NA correlation.
PFC-NA Binding (associated) of associated with nucleus accumbens
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0.12 Pain Relevance 0.30
to the mPFC is associated with extinction maintenance

[68, 69].

mPFC Binding (associated) of
8) Confidence 0.25 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 1.11 Pain Relevance 0.20
subjects indicate that the mPFC is engaged during extinction

[70] and that subjects with PTSD have reduced mPFC activity during trauma recall [71].

mPFC Binding (engaged) of associated with post-traumatic stress disorder and injury
9) Confidence 0.19 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 1.25 Pain Relevance 0.19
2.174, p<0.05; Fig. 1D), as opposed to the increased phosphorylation level of Ser880-GluA2 site observed in the mPFC (t (19)?
mPFC Binding (observed) of
10) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.52
In PFC, a significant difference between the groups in 5-HTT binding (t = ? 
PFC Binding (binding) of
11) Confidence 0.15 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.33 Pain Relevance 0.07
The dorsolateral PFC is engaged in executive functions such as working memory, whereas the ventromedial PFC is part of the limbic system involved in decision making and social cognition [42].
PFC Binding (engaged) of associated with cognitive disorder and limbic system
12) Confidence 0.10 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.71 Pain Relevance 0.09
These control regions were selected on the basis of their known connectivity with the mPFC (e.g.
mPFC Binding (connectivity) of
13) Confidence 0.07 Published 2010 Journal Neuroscience Section Body Doc Link PMC2930211 Disease Relevance 0.09 Pain Relevance 0.53
Moreover, hemispheric specialization in mPFC may mediate adaptive coping responses to stress.
mPFC Binding (specialization) of associated with stress
14) Confidence 0.06 Published 2008 Journal Neuroscience Section Abstract Doc Link 18634856 Disease Relevance 0.35 Pain Relevance 0.15
The present findings suggest that mPFC and iCA1 are necessary and interact during encoding and retrieval; however, the OFC does not appear to be essential for either process.
mPFC Binding (interact) of in OFC
15) Confidence 0.06 Published 2010 Journal Neurobiol Learn Mem Section Abstract Doc Link 20074655 Disease Relevance 0 Pain Relevance 0.22
While the nature of the interaction between mPFC and iCA1 during encoding and retrieval is unclear, it may be supported by the integration of goals and spatial cues or strategy switching.
mPFC Binding (interaction) of
16) Confidence 0.05 Published 2010 Journal Neurobiol Learn Mem Section Abstract Doc Link 20074655 Disease Relevance 0 Pain Relevance 0.18
ADHD: Attention-Deficit/Hyperactivity Disorder; MP: methylphenidate; PFC: prefrontal cortex; MA: methamphetamine; DA: dopamine; BLA: basolateral amygdala; CA: central amygdala

Competing interests

PFC Binding (cortex) of in amygdala associated with dopamine, attention deficit hyperactivity disorder and amygdala
17) Confidence 0.04 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2412842 Disease Relevance 0.20 Pain Relevance 0.32
These results suggest that top–down control arises from specific interactions between mPFC and RFA, and does not involve processing in IC.
mPFC Binding (interactions) of
18) Confidence 0.03 Published 2010 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2965050 Disease Relevance 0 Pain Relevance 0
PFC cultures were treated with a dynamin inhibitory peptide, which competes for binding to amphiphysin and hence inhibits the clathrin/dynamin-dependent endocytosis (35).
PFC Binding (binding) of
19) Confidence 0.03 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.13
Together, these studies suggest that RFA is a premotor region in the rat frontal cortex that competes with mPFC to control action selection.
mPFC Binding (competes) of in frontal cortex associated with urological neuroanatomy
20) Confidence 0.03 Published 2010 Journal Frontiers in Integrative Neuroscience Section Abstract Doc Link PMC2965050 Disease Relevance 0.23 Pain Relevance 0

General Comments

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