INT15339

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.34
Pain Relevance 6.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
nerve 2
sciatic nerve 1
endothelium 1
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 78 100.00 Very High Very High Very High
qutenza 78 100.00 Very High Very High Very High
Hyperalgesia 21 100.00 Very High Very High Very High
Brush evoked pain 8 99.80 Very High Very High Very High
Calcitonin gene-related peptide 5 99.40 Very High Very High Very High
Sciatic nerve 23 99.32 Very High Very High Very High
intrathecal 29 99.12 Very High Very High Very High
substance P 13 99.00 Very High Very High Very High
antinociception 1 98.76 Very High Very High Very High
Inflammatory stimuli 1 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 72 100.00 Very High Very High Very High
Hyperalgesia 32 100.00 Very High Very High Very High
Neuropathic Pain 16 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.52 Very High Very High Very High
Interstitial Cystitis 6 93.68 High High
Ganglion Cysts 38 93.36 High High
Pain 47 91.60 High High
Nociception 40 90.00 High High
Pressure And Volume Under Development 5 89.76 High High
Injury 7 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, RTX treatment did not affect the tactile allodynia seen in the same nerve-injured rats.
Neg (not) Regulation (affect) of RTX in nerve associated with brush evoked pain
1) Confidence 0.45 Published 1999 Journal Pain Section Abstract Doc Link 10068158 Disease Relevance 1.13 Pain Relevance 1.54
Six studies provided contradictory results regarding the effectiveness of resiniferatoxin treatment.
Regulation (effectiveness) of resiniferatoxin
2) Confidence 0.35 Published 2008 Journal Int Urogynecol J Pelvic Floor Dysfunct Section Abstract Doc Link 18563284 Disease Relevance 0.32 Pain Relevance 0.32
Three other articles that studied the effectiveness of a single dose of resiniferatoxin gave contradictory results.
Regulation (effectiveness) of resiniferatoxin
3) Confidence 0.35 Published 2008 Journal Int Urogynecol J Pelvic Floor Dysfunct Section Abstract Doc Link 18563284 Disease Relevance 0.32 Pain Relevance 0.39
The effect of a single subcutaneous (s.c.) injection of the ultrapotent capsaicin analogue resiniferatoxin (RTX) on responses of adult rats to noxious thermal and mechanical stimulation was examined.
Spec (examined) Regulation (effect) of RTX associated with qutenza
4) Confidence 0.14 Published 1997 Journal Brain Res. Section Abstract Doc Link 9106440 Disease Relevance 0.36 Pain Relevance 0.42
In contrast, responses to the C stimulus were not significantly different between the RTX and vehicle groups by day 18.
Neg (not) Regulation (different) of RTX
5) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0 Pain Relevance 0.43
Preprotachykinin (PPT) mRNA, TRPV1 mRNA and TRPV1 protein expression decreased in CAP-treated cultures and RTX cultures treated with the higher concentration, whereas RTX cultures treated with the lower concentration were not affected.
Neg (not) Regulation (affected) of RTX associated with qutenza
6) Confidence 0.12 Published 2010 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 20383340 Disease Relevance 0.48 Pain Relevance 1.36
RTX blocks inflammatory heat hyperalgesia when applied directly to the sciatic nerve in a time and dose dependent fashion
Regulation (applied) of RTX in sciatic nerve associated with hyperalgesia, inflammation and sciatic nerve
7) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.77 Pain Relevance 0.68
Regeneration of nerve terminals following RTX treatment
Regulation (following) of RTX in nerve
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.47 Pain Relevance 0.41
Incubation with methylene blue, an inhibitor of endothelium-derived relaxing factor mechanisms, which completely blocked the substance P-evoked vasodilatation, as well as substance P-tachyphylaxis, did not influence the vasodilator response to resiniferatoxin, capsaicin or calcitonin gene-related peptide.
Regulation (response) of resiniferatoxin in endothelium associated with qutenza, increased venous pressure under development, calcitonin gene-related peptide and substance p
9) Confidence 0.00 Published 1991 Journal Acta Physiol. Scand. Section Abstract Doc Link 1722940 Disease Relevance 0.49 Pain Relevance 0.94

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