INT153409

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.01
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
SNL 2
myeloid progenitor cell 1
bone marrow 1
Jak2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 44 99.36 Very High Very High Very High
Spinal cord 5 99.36 Very High Very High Very High
Potency 52 98.96 Very High Very High Very High
allodynia 1 98.64 Very High Very High Very High
Thermal hyperalgesia 1 98.08 Very High Very High Very High
Inflammation 42 96.12 Very High Very High Very High
intrathecal 1 94.84 High High
cytokine 60 90.00 High High
Neuropathic pain 2 80.88 Quite High
Peripheral nerve injury 2 79.56 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 44 99.36 Very High Very High Very High
Reprotox - General 1 2 98.96 Very High Very High Very High
Neuropathic Pain 3 98.64 Very High Very High Very High
Hyperalgesia 1 98.08 Very High Very High Very High
INFLAMMATION 40 96.12 Very High Very High Very High
Injury 1 90.24 High High
Nervous System Injury 2 79.56 Quite High
Pain 2 72.44 Quite High
Psoriasis 6 50.64 Quite High
Arthritis 104 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the inhibitor demonstrated reduced potency against IL-6 activation of STAT3 and significantly reduced inhibition of JAK2-mediated GM-CSF signaling.
Negative_regulation (reduced) of Negative_regulation (inhibition) of JAK2 associated with reprotox - general 1 and potency
1) Confidence 0.34 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.10 Pain Relevance 0.43
The two most likely mechanistic hypotheses which could explain observed clinical reductions in PBNC in RA subjects by CP-690,550 are: 1) suppression of bone marrow myeloid progenitor cell differentiation via a loss of selectivity and inhibition of JAK2; and 2) suppression of chemotactic and hematopoietic growth factors as an extension of the anti-inflammatory activity of CP-690,550.
Negative_regulation (suppression) of in bone marrow Negative_regulation (inhibition) of JAK2 in myeloid progenitor cell associated with inflammation and rheumatoid arthritis
2) Confidence 0.34 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.25 Pain Relevance 0.19
STAT3 pathway blockade with Janus kinase 2 inhibitor AG490 attenuated both mechanical allodynia and thermal hyperalgesia in SNL rats.
Negative_regulation (blockade) of Negative_regulation (inhibitor) of Janus kinase 2 in SNL associated with allodynia and thermal hyperalgesia
3) Confidence 0.27 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.67 Pain Relevance 0.91

General Comments

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