INT153411

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.24
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Jak1) cytoplasm (Jak1)
Anatomy Link Frequency
spinal cord 1
microglia 1
Jak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 11 99.84 Very High Very High Very High
Peripheral nerve injury 5 98.72 Very High Very High Very High
cytokine 62 97.84 Very High Very High Very High
Inflammatory response 1 97.56 Very High Very High Very High
Neuropathic pain 4 97.00 Very High Very High Very High
Potency 52 94.56 High High
Inflammation 43 91.52 High High
Pain 4 82.12 Quite High
allodynia 4 75.00 Quite High
intrathecal 2 60.00 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 5 98.28 Very High Very High Very High
INFLAMMATION 42 97.20 Very High Very High Very High
Neuropathic Pain 8 97.00 Very High Very High Very High
Pain 2 82.12 Quite High
Reprotox - General 1 2 71.76 Quite High
Hyperalgesia 1 50.96 Quite High
Injury 2 48.00 Quite Low
Hypersensitivity 1 37.92 Quite Low
Arthritis 104 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat.
Positive_regulation (activated) of JAK in spinal cord associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
1) Confidence 0.49 Published 2008 Journal J. Neurochem. Section Title Doc Link 18636982 Disease Relevance 0.53 Pain Relevance 0.74
activation of STAT1 through JAK1/2 or JAK1/Tyk2, respectively.
Positive_regulation (activation) of JAK1
2) Confidence 0.36 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.07 Pain Relevance 0.44
activation of STAT1 through JAK1/2 or JAK1/Tyk2, respectively.
Positive_regulation (activation) of JAK1
3) Confidence 0.36 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.07 Pain Relevance 0.44
We showed recently that spinal nerve lesion leads to rapid activation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signal transduction pathway in dorsal spinal cord microglia in relation with enhanced levels of spinal interleukin-6 (IL-6) protein.
Positive_regulation (activation) of Janus kinase in microglia associated with spinal cord
4) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410127 Disease Relevance 0.57 Pain Relevance 0.63

General Comments

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