INT153430

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.92
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
lung 2
plasma 1
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 232 86.60 High High
metalloproteinase 152 81.84 Quite High
dorsal root ganglion 1 80.92 Quite High
Hsan 1 60.60 Quite High
Inflammatory mediators 36 57.36 Quite High
fibrosis 36 9.64 Low Low
cytokine 24 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Emphysema 20 97.72 Very High Very High Very High
Stress 1 89.16 High High
INFLAMMATION 200 86.60 High High
Adhesions 8 85.96 High High
Congenital Anomalies 1 84.88 Quite High
Pulmonary Disease 352 84.72 Quite High
Ganglion Cysts 1 80.92 Quite High
Disease 10 77.36 Quite High
Dystonia 1 64.96 Quite High
Hereditary Sensory And Autonomic Neuropathies 1 60.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This isoform also interacts with the NE protein nesprin-3alpha, but not nesprin-3beta.
NE Binding (interacts) of
1) Confidence 0.47 Published 2008 Journal Exp. Cell Res. Section Abstract Doc Link 18638474 Disease Relevance 0.52 Pain Relevance 0.10
NE binds very stably to elastin in an active form, and ?
NE Binding (binds) of
2) Confidence 0.09 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.30 Pain Relevance 0.08
While unrestrained NE activity in the lung is likely to be important in the panlobular pulmonary emphysema associated with ?
NE Binding (activity) of in lung associated with pulmonary emphysema
3) Confidence 0.07 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.67 Pain Relevance 0.16
Since NE is bound to interstitial elastin in human emphysematous lungs (Damiano et al 1986), lung elastin-bound NE likely retains catalytic activity and contributes critically to destruction of elastin fibers in pulmonary emphysema (Figure 4).
NE Binding (bound) of in lung associated with pulmonary emphysema
4) Confidence 0.07 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.30 Pain Relevance 0.08
The inhibitor-resistance of membrane-bound NE is due to positive residues in NE binding to negatively charged sulfate groups in PMN plasma membrane proteoglycans (Campbell and Owen 2007), but the mechanism underlying the resistance of other cell-surface proteinases to inhibition is not known.
NE Binding (binding) of in plasma
5) Confidence 0.06 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox