INT153436

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.12
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
poly 2
cleavage 2
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 93.76 High High
antagonist 1 89.48 High High
cINOD 1 59.92 Quite High
palliative 1 52.24 Quite High
Bioavailability 2 10.16 Low Low
imagery 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 2 99.50 Very High Very High Very High
Apoptosis 35 98.32 Very High Very High Very High
Cancer 55 97.80 Very High Very High Very High
INFLAMMATION 10 93.76 High High
Aging 2 65.04 Quite High
Disease 3 63.76 Quite High
Metastasis 4 62.88 Quite High
Skin Cancer 53 50.00 Quite Low
Neuroblastoma 47 50.00 Quite Low
Solid Tumor 3 14.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proapoptotic effect of rolipram was associated with decreased levels of the prosurvival protein Mcl-1 and increased caspase-3 cleavage.
Positive_regulation (increased) of Localization (cleavage) of caspase-3 in cleavage
1) Confidence 0.49 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.76 Pain Relevance 0.31
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Positive_regulation (activation) of Localization (cleavage) of caspase-3 in poly associated with cancer and apoptosis
2) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.10 Pain Relevance 0.07
Both eyeblink classical conditioning (EBCC) and object recognition memory (ORM) induced an increase in histone H3 acetylation (Ac-H3).
Positive_regulation (increase) of Localization (acetylation) of Ac-H3 associated with cognitive disorder
3) Confidence 0.08 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18638560 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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