INT153441

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 4.95
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KIR2DS5)
Anatomy Link Frequency
NK cells 1
kidney 1
KIR2DS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 106 99.84 Very High Very High Very High
rheumatoid arthritis 28 98.20 Very High Very High Very High
tolerance 12 97.72 Very High Very High Very High
endometriosis 48 89.20 High High
psoriasis 8 68.52 Quite High
pain pelvic 4 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 106 99.84 Very High Very High Very High
Graft Vs Host Disease 24 98.24 Very High Very High Very High
Rheumatoid Arthritis 28 98.20 Very High Very High Very High
Leukemia 44 97.72 Very High Very High Very High
Reprotox - General 3 20 97.20 Very High Very High Very High
Lung Cancer 28 95.44 Very High Very High Very High
Autoimmune Disease 8 94.52 High High
Endometriosis (extended) 48 89.20 High High
Disease 60 88.48 High High
Psoriasis 8 68.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore we may speculate that the presence of KIR2DS5 contributes to the activation of NK cells, leading to a more efficient induction of tolerance and inhibition of allograft rejection and autoimmunity.
Gene_expression (presence) of KIR2DS5 in NK cells associated with autoimmune disease and tolerance
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 1.18 Pain Relevance 0.59
In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p?
Gene_expression (gene) of KIR2DS5 associated with spinal inflammation
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2928722 Disease Relevance 1.02 Pain Relevance 0.39
The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p?
Gene_expression (presence) of KIR2DS5 in kidney associated with graft vs host disease
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2928722 Disease Relevance 1.04 Pain Relevance 0.41
A similar increase was reported in the Thai population: KIR3DS1, KIR2DS5, and KIR2DL5 gene frequencies were higher in AS (p(c) < 0.05, p < 0.05, and p(c) < 0.05, respectively).
Gene_expression (higher) of KIR2DS5 associated with spinal inflammation
4) Confidence 0.66 Published 2008 Journal Hum. Immunol. Section Abstract Doc Link 18638658 Disease Relevance 0.52 Pain Relevance 0.59
A similar increase was reported in the Thai population: KIR3DS1, KIR2DS5, and KIR2DL5 gene frequencies were higher in AS (p(c) < 0.05, p < 0.05, and p(c) < 0.05, respectively).
Gene_expression (frequencies) of KIR2DS5 associated with spinal inflammation
5) Confidence 0.66 Published 2008 Journal Hum. Immunol. Section Abstract Doc Link 18638658 Disease Relevance 0.52 Pain Relevance 0.59
We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others.
Gene_expression (presence) of KIR2DS5
6) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2928722 Disease Relevance 0.68 Pain Relevance 0.23

General Comments

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