INT153495

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.51
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pmp22) plasma membrane (Pmp22) cell cycle (Pmp22)
Anatomy Link Frequency
elbow 1
Pmp22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 7 97.36 Very High Very High Very High
peripheral neuropathy 5 95.84 Very High Very High Very High
Demyelination 1 86.00 High High
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
Sciatica 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathy 19 99.98 Very High Very High Very High
Demyelinating Disease 13 99.68 Very High Very High Very High
Ulnar Neuropathies 16 98.72 Very High Very High Very High
Median Neuropathy 7 98.02 Very High Very High Very High
Carpal Tunnel Syndrome 8 97.36 Very High Very High Very High
Mononeuropathies 3 97.20 Very High Very High Very High
Peripheral Neuropathy 5 95.84 Very High Very High Very High
Paralysis 35 95.74 Very High Very High Very High
Neuropathic Pain 2 92.96 High High
Frailty 3 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This mutation, which has not been reported previously, leads to an open reading frame shift and probably to a truncated and unstable PMP22 protein.
PMP22 protein Binding (leads) of
1) Confidence 0.37 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 18642376 Disease Relevance 0.41 Pain Relevance 0.12
They presented an unusual combination of clinical, electrophysiological, and pathological findings in association with a new mutation of the PMP22 gene.
PMP22 gene Binding (association) of
2) Confidence 0.37 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 18642376 Disease Relevance 0.36 Pain Relevance 0.15
HNPP can present with unusual phenotypes, such as 5 separate mononeuropathies, bilateral ulnar and median neuropathies at the wrists and ulnar neuropathy at the elbow with mild peripheral demyelinating polyneuropathy associated with the PMP-22 gene deletion.



PMP-22 Binding (associated) of in elbow associated with neuropathy, median neuropathy, ulnar neuropathies, mononeuropathies, demyelinating disease and paralysis
3) Confidence 0.06 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2248584 Disease Relevance 1.74 Pain Relevance 0.08

General Comments

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