INT15350

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Context Info
Confidence 0.81
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 6.86
Pain Relevance 10.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
pituitary 3
blood 1
plasma 1
stromal cells 1
colon 1
Prl (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 15 99.78 Very High Very High Very High
tricyclic antidepressant 1 99.76 Very High Very High Very High
antagonist 19 99.74 Very High Very High Very High
Dopamine 34 99.70 Very High Very High Very High
Morphine 15 99.58 Very High Very High Very High
ketamine 6 99.36 Very High Very High Very High
Endogenous opioid 4 99.22 Very High Very High Very High
Clonidine 16 99.20 Very High Very High Very High
anesthesia 4 98.96 Very High Very High Very High
Opioid 7 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pituitary Cancer 130 99.98 Very High Very High Very High
Cancer 256 99.92 Very High Very High Very High
Stress 3 99.76 Very High Very High Very High
Gynecomastia 1 99.36 Very High Very High Very High
Colon Cancer 8 99.24 Very High Very High Very High
Targeted Disruption 19 98.52 Very High Very High Very High
Adenoma 45 98.00 Very High Very High Very High
Dysmenorrhea 4 96.46 Very High Very High Very High
Reprotox - General 3 7 95.24 Very High Very High Very High
Carcinoma 35 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Development of uterine adenomyosis was studied in SHN mice treated with psychotherapeutic drugs, sulpiride and perphenazine, and gastroenteric drug, metoclopramide, which act as dopamine antagonists to increase prolactin release from the pituitary gland.
Localization (release) of prolactin in uterine associated with dopamine, antagonist and dismenorea
1) Confidence 0.81 Published 1991 Journal Life Sci. Section Abstract Doc Link 2062175 Disease Relevance 0.32 Pain Relevance 0.48
Taken together, this series of experiments provides convincing evidence for the dopamine inhibition of prolactin release being the final pathway for pheromone action in the context of pregnancy block.
Localization (release) of prolactin associated with dopamine
2) Confidence 0.80 Published 1989 Journal J. Reprod. Fertil. Section Abstract Doc Link 2513390 Disease Relevance 0 Pain Relevance 0.31
The phenothiazines and tricyclic antidepressants may induce prolactin secretion and consequent gynecomastia.
Localization (secretion) of prolactin associated with tricyclic antidepressant and gynecomastia
3) Confidence 0.62 Published 1987 Journal Adv Contracept Deliv Syst Section Abstract Doc Link 12341906 Disease Relevance 0.67 Pain Relevance 0.41
Both (+)3PPP and (-) butaclamol decreased the release of prolactin and did not affect the metabolism of DA.
Localization (release) of prolactin associated with dopamine
4) Confidence 0.54 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1723511 Disease Relevance 0 Pain Relevance 0.59
N-Allyl-normetazocine and (+)pentazocine increased release of prolactin and have been shown previously to increase the metabolism of DA.
Localization (release) of prolactin associated with fortral and dopamine
5) Confidence 0.54 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1723511 Disease Relevance 0 Pain Relevance 0.64
The effects of sigma ligands, (+)3PPP 3-[3-hydroxyphenyl-N(1-propyl) piperidine] and (-)butaclamol, were evaluated in vivo on the metabolism of dopamine (DA) and in the striatum release of adrenocorticotrophic hormone (ACTH) and prolactin in the rat and changes in levels of cyclic guanosine monophosphate (cGMP) in the cerebellum of the mouse and compared with the effects of (+)NANM (N-allyl-normetazocine, SKF 10,047) and (+)pentazocine.
Localization (release) of prolactin in cerebellum associated with fortral and dopamine
6) Confidence 0.50 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1723511 Disease Relevance 0 Pain Relevance 0.39
PrRP has been shown to be involved in the regulation of food intake, stress responses, prolactin secretion and release, blood pressure, and the opioid system.
Localization (secretion) of prolactin in blood associated with stress and opioid
7) Confidence 0.42 Published 2009 Journal Peptides Section Abstract Doc Link 19540425 Disease Relevance 0.67 Pain Relevance 0.17
These results suggest that the synthesis of NPY, ENK and NT is enhanced in TIDA neurons during lactation and that these neuromessengers may be co-released together with DA from the ME to regulate the suckling-induced prolactin secretion at the hypothalamic and/or pituitary levels.
Localization (secretion) of prolactin in neurons associated with enkephalin
8) Confidence 0.35 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.08 Pain Relevance 0.59
Like adenomas, the vast majority of reported pituitary carcinomas are endocrinologically active (88%), with most secreting adrenocorticotrophic hormone (ACTH) or prolactin (PRL)[3].
Localization (secreting) of PRL in pituitary associated with adenoma and pituitary cancer
9) Confidence 0.30 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.25 Pain Relevance 0.16
Like adenomas, the vast majority of reported pituitary carcinomas are endocrinologically active (88%), with most secreting adrenocorticotrophic hormone (ACTH) or prolactin (PRL)[3].
Localization (secreting) of prolactin in pituitary associated with adenoma and pituitary cancer
10) Confidence 0.30 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.25 Pain Relevance 0.16
On the contrary clonidine was able to increase GH and TSH levels and to decrease cortisol levels; PRL secretion was not affected.
Localization (secretion) of PRL associated with clonidine
11) Confidence 0.23 Published 1987 Journal Biomed. Pharmacother. Section Abstract Doc Link 3663877 Disease Relevance 0 Pain Relevance 1.64
As regards interaction between morphine and clonidine we observed that morphine-induced increase in PRL release was potentiated by clonidine pretreatment; as regards TSH secretion its increase was greater after the administration of the two drugs with respect to the effect of the single drugs.
Localization (release) of PRL associated with clonidine and morphine
12) Confidence 0.23 Published 1987 Journal Biomed. Pharmacother. Section Abstract Doc Link 3663877 Disease Relevance 0 Pain Relevance 1.63
The efficacy of cabergoline was somewhat better in tumors co-secreting prolactin.
Localization (secreting) of prolactin associated with cancer
13) Confidence 0.16 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.66 Pain Relevance 0.56
In fact, transgenic mice expressing high levels of the HMGA2 gene develop pituitary adenomas secreting prolactin and growth hormone [6], (Figure 1).
Localization (secreting) of prolactin in pituitary associated with targeted disruption and pituitary cancer
14) Confidence 0.12 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.78 Pain Relevance 0.06
The 16 kD prolactin fragment was expressed and secreted from HCT116 human colon cancer cells stably transfected with an expression vector encoding the 16 kD prolactin fragement gene.
Localization (secreted) of prolactin in colon associated with colon cancer
15) Confidence 0.10 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.78 Pain Relevance 0.03
The excitatory amino acids (EAAs), glutamate and aspartate, acting predominantly on N-methyl-D-aspartate (NMDA) receptor, have been shown to be involved in the central regulation of the secretion of several anterior pituitary hormones including prolactin (PRL), whereas ketamine hydrochloride (KH), a widely used anesthetic, has been reported to antagonize a variety of NMDA receptor mediated actions of these EAAs.
Localization (secretion) of prolactin in anterior pituitary associated with glutamate, ketamine, nmda receptor and excitatory amino acid
16) Confidence 0.09 Published 2001 Journal Life Sci. Section Abstract Doc Link 11212871 Disease Relevance 0 Pain Relevance 0.48
The effect of ketamine hydrochloride anesthesia on basal and N-methyl-D,L-aspartate induced plasma prolactin secretion in the adult male rhesus monkey.
Localization (secretion) of prolactin in plasma associated with anesthesia and ketamine
17) Confidence 0.09 Published 2001 Journal Life Sci. Section Title Doc Link 11212871 Disease Relevance 0 Pain Relevance 0.50
Treatment of human endometrial stromal cells in culture with recombinant human IL-11 increases their secretion of the decidual markers prolactin and insulin-like growth factor binding protein (IGFBP)-1, and is associated with enhanced differentiation [21].
Localization (secretion) of prolactin in stromal cells
18) Confidence 0.08 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.09 Pain Relevance 0.04
A possible role for endogenous opioid peptides (EOP) in the control of luteinizing hormone (LH) and prolactin (PRL) secretion was studied by injecting the opioid antagonist, naloxone (NAL), into postpartum ewes and cows.
Localization (secretion) of prolactin associated with antagonist, narcan, endogenous opioid and opioid
19) Confidence 0.07 Published 1986 Journal J. Anim. Sci. Section Abstract Doc Link 3759712 Disease Relevance 0 Pain Relevance 0.53
Endogenous opioid modulation of luteinizing hormone and prolactin secretion in postpartum ewes and cows.
Localization (secretion) of prolactin associated with endogenous opioid
20) Confidence 0.07 Published 1986 Journal J. Anim. Sci. Section Title Doc Link 3759712 Disease Relevance 0 Pain Relevance 0.69

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