INT153514

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
NAc 2
keratinocytes 2
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 11 99.32 Very High Very High Very High
Nucleus accumbens 7 98.52 Very High Very High Very High
Dopamine 5 94.16 High High
Inflammation 27 84.60 Quite High
Morphine 1 75.08 Quite High
addiction 3 65.68 Quite High
cytokine 1 64.00 Quite High
midbrain 1 56.96 Quite High
Ventral tegmentum 1 56.32 Quite High
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 84.60 Quite High
Pressure And Volume Under Development 31 80.56 Quite High
Drug Dependence 1 65.68 Quite High
Nicotine Addiction 4 50.56 Quite High
Disease 1 45.68 Quite Low
Necrosis 2 5.00 Very Low Very Low Very Low
Skin Diseases 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Dermatitis 1 5.00 Very Low Very Low Very Low
Psoriasis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc.
Positive_regulation (promoted) of Localization (release) of tPA in NAc associated with nucleus accumbens and nicotine
1) Confidence 0.62 Published 2008 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 18646640 Disease Relevance 0.12 Pain Relevance 1.05
secretion in TPA-treated keratinocytes
Positive_regulation (treated) of Localization (secretion) of TPA in keratinocytes
2) Confidence 0.12 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.43 Pain Relevance 0.18

General Comments

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