INT153515

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.21
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
astrocytes 3
NAc 1
growth cones 1
MSCs 1
Plaque 1
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 1 100.00 Very High Very High Very High
Nicotine 11 99.06 Very High Very High Very High
Nucleus accumbens 7 98.52 Very High Very High Very High
Dopamine 5 93.64 High High
cva 5 90.08 High High
Inflammation 39 84.60 Quite High
Morphine 1 74.56 Quite High
Central nervous system 37 72.88 Quite High
addiction 3 65.16 Quite High
cytokine 5 63.36 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 144 99.92 Very High Very High Very High
Stroke 110 99.56 Very High Very High Very High
Targeted Disruption 32 98.08 Very High Very High Very High
Convulsion 1 93.76 High High
Disease 29 93.24 High High
Dementia 9 92.36 High High
Cv General 3 Under Development 3 90.08 High High
Cicatrix 16 88.52 High High
Hyperlipidemia 3 85.92 High High
INFLAMMATION 52 84.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To verify the neurite outgrowth promoting effect of tPA secreted by astrocytes, the siRNA technique was used to knock-down the tPA expression in astrocytes.
Localization (secreted) of tPA in astrocytes associated with targeted disruption
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.30 Pain Relevance 0
Early after stroke, reactive astrocytes secrete abundant factors, such as tPA as well as PAI-1 [24], [81]–[83].
Localization (secrete) of tPA in astrocytes associated with stroke
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.52 Pain Relevance 0
Normal cultured astrocytes secreted tPA at a concentration of 1.27±0.02 ng/mL, and normal astrocytes co-cultured with MSCs significantly (p<0.05) increased the tPA concentration to 1.32±0.01 ng/mL.
Localization (secreted) of tPA in astrocytes
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0 Pain Relevance 0
Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc.
Localization (release) of tPA in NAc associated with nucleus accumbens and nicotine
4) Confidence 0.72 Published 2008 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 18646640 Disease Relevance 0.12 Pain Relevance 1.02
Total Plaque Area (TPA) measurement
Localization (measurement) of TPA in Plaque
5) Confidence 0.65 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1657034 Disease Relevance 0 Pain Relevance 0
ELISA analysis of conditioned medium revealed that MSCs stimulated astrocytes to secrete tPA.
Localization (secrete) of tPA in MSCs
6) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815778 Disease Relevance 0.39 Pain Relevance 0.07
If microglia directly modulate the extracellular space, they may do this through the secretion of various proteases that degrade extracellular matrix proteins, including cathepsins, metalloproteases, and tissue-type plasminogen activator [35].
Localization (secretion) of tissue-type plasminogen activator in extracellular matrix
7) Confidence 0.28 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0
This correlation may reflect the in vitro inhibitory effect of HDL on tPA and PAI secretion by the endothelium (Ren and Shen 2000).
Localization (secretion) of tPA in endothelium associated with disorder of lipid metabolism
8) Confidence 0.20 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.23 Pain Relevance 0.03
secretion in TPA-treated keratinocytes
Localization (secretion) of TPA in keratinocytes
9) Confidence 0.17 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.43 Pain Relevance 0.18
Wild-type neuroserpin is secreted from the axonal growth cones of the central and peripheral nervous system and inhibits tissue plasminogen activator (15–19).
Localization (secreted) of tissue plasminogen activator in growth cones associated with peripheral nervous system
10) Confidence 0.04 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2387220 Disease Relevance 1.23 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox