INT153530

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.17
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NMS)
Anatomy Link Frequency
neuronal 2
NMS (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 6 97.96 Very High Very High Very High
Anterior cingulate cortex 6 96.76 Very High Very High Very High
Dorsal horn 10 96.40 Very High Very High Very High
Rostral ventromedial medulla 4 91.88 High High
amygdala 3 90.48 High High
Pain 12 84.56 Quite High
nud 4 75.44 Quite High
Thalamus 2 67.84 Quite High
nociceptor 1 25.00 Low Low
Dopamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroleptic Malignant Syndrome 32 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

16 100.00 Very High Very High Very High
Hyperalgesia 6 97.96 Very High Very High Very High
Dyskinesias 5 87.00 High High
Pain 8 84.56 Quite High
Akathisia 1 83.96 Quite High
Syndrome 2 80.24 Quite High
Fever 1 78.08 Quite High
Delirium 2 77.28 Quite High
Muscle Rigidity 1 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that ERK is actively involved in CRD-evoked neuronal activation in both NH and NMS rats.
Positive_regulation (activation) of NMS in neuronal associated with neuroleptic malignant syndrome
1) Confidence 0.39 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 18649147 Disease Relevance 0.51 Pain Relevance 0.49
Moreover, ERK is associated with the upregulated central neuronal sensitivity to noxious CRD in NMS rats, which may be responsible for the behavioral hyperalgesia in NMS rat.
Positive_regulation (upregulated) of NMS in neuronal associated with hyperalgesia and neuroleptic malignant syndrome
2) Confidence 0.39 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 18649147 Disease Relevance 0.64 Pain Relevance 0.49
Expression of BDNF and TrkB following NMS and CRD stimulation was determined using immunohistochemistry.
Positive_regulation (stimulation) of NMS associated with neuroleptic malignant syndrome
3) Confidence 0.35 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.07 Pain Relevance 0.65
The features of clozapine-induced NMS may be somewhat different, with fewer extrapyramidal side effects and a lower rise in creatine kinase levels.
Positive_regulation (induced) of NMS associated with neuroleptic malignant syndrome
4) Confidence 0.05 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2910351 Disease Relevance 1.13 Pain Relevance 0

General Comments

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